4-Chlor-benzaldehyd-<4,4-dimethyl-semicarbazon> | 5499-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chlor-benzaldehyd-<4,4-dimethyl-semicarbazon>
• 英文别名: 4-Chlor-benzaldehyd-(4,4-dimethyl-semicarbazon)；3-[(4-Chlorophenyl)methylideneamino]-1,1-dimethylurea
• CAS: 5499-37-6
• 化学式: C₁₀H₁₂ClN₃O
• 分子量: 225.678
• InChiKey: QIISRYVRKLRDRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基-1,1-二甲基脲 、 4-氯苯甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 4-Chlor-benzaldehyd-<4,4-dimethyl-semicarbazon>
  参考文献：
  名称：

  4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents

  摘要：

  Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.

  DOI：

  10.1021/jm00221a034

文献信息

• 4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents
  作者：James D. Warren、David L. Woodward、Ronald T. Hargreaves

  DOI：10.1021/jm00221a034

  日期：1977.11

  Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.