1-(2-二甲氨基苯基)丙醇 | 156054-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-二甲氨基苯基)丙醇
• 英文名称: 1-(2-dimethylaminophenyl)propanol
• 英文别名: 1-[2-(Dimethylamino)phenyl]propan-1-ol
• CAS: 156054-91-0
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: JWPVLPNABDVXOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-二甲氨基苯基)丙醇 在 溴 、 三丁基氧化锡 作用下， 以98%的产率得到2-溴-N,N-二甲基苯胺
  参考文献：
  名称：

  Synthesis of Isobenzofuran Derivatives as heterocyclic analogues of the herbicidesindone B

  摘要：

  The target compounds 21-27 were synthesized via bromination of the N,N,1,1-tetramethylisobenzofuranamines 13, 15 and 16, subsequent bromine-lithium exchange and reaction with propanal or propanoyl chloride, respectively. In the course of some model reactions undertaken to test a synthetic strategy based on directed ortho-lithiation governed by the dimethylamino-group a useful synthesis of the ketone 3 was developed.

  DOI：

  10.1002/prac.19943360411
• 作为产物：
  描述：

  丙醛 、 N,N-二甲基苯胺 在 正丁基锂 、 四甲基乙二胺 作用下， 生成 1-(2-二甲氨基苯基)丙醇
  参考文献：
  名称：

  Synthesis of Isobenzofuran Derivatives as heterocyclic analogues of the herbicidesindone B

  摘要：

  The target compounds 21-27 were synthesized via bromination of the N,N,1,1-tetramethylisobenzofuranamines 13, 15 and 16, subsequent bromine-lithium exchange and reaction with propanal or propanoyl chloride, respectively. In the course of some model reactions undertaken to test a synthetic strategy based on directed ortho-lithiation governed by the dimethylamino-group a useful synthesis of the ketone 3 was developed.

  DOI：

  10.1002/prac.19943360411

文献信息

• [EN] PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE CARBAMATES CYCLIQUES
  申请人：LONZA AG

  公开号：WO2012048884A1

  公开（公告）日：2012-04-19

  The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C2-5-alkyl C2-5-carboxylates and mixtures of at least one C2-5-alkyl C2-5-carboxylate with at least one C5-8-alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.

  本发明涉及一种以手性炔丙醇和/或适当的盐为起始物，通过选择光气、二光气、三光气及其混合物作为环化剂进行反应，以制备环状碳酸酯的方法，其中反应在水性碱和与水不混溶的有机溶剂的存在下进行，所述有机溶剂主要由至少一种C2-5-烷基C2-5-羧酸酯和至少一种C2-5-烷基C2-5-羧酸酯与至少一种C5-8-烷烃的混合物组成。发明的另一方面涉及上述描述的环状碳酸酯的合成过程，其中还提供了制备手性炔丙醇的方法。
• PROCESS FOR PREPARATING OPTICALLY ACTIVE COMPOUNDS
  申请人：Japan Science and Technology Corporation

  公开号：EP0916637A1

  公开（公告）日：1999-05-19

  The present invention relates to a novel, highly practical method for producing optically active compounds such as optically active alcohol and optically active amine useful for various utilities such as synthetic intermediates of drugs, liquid crystal materials, and optical resolution agents, comprising hydrogen transfer-type asymmetric reduction in the presence of a transition metal catalyst and an optically active nitrogen-containing compound or a transition metal catalyst with an optically active nitrogen-containing compound as the asymmetric ligand, and a hydrogen-donating organic or inorganic compound. In accordance with the present invention, characteristically, an optically active secondary alcohol can be recovered through the hydrogen transfer-type oxidation from racemic secondary alcohol or meso-type diol.

  本发明涉及一种生产光学活性化合物（如光学活性醇和光学活性胺）的新型、高度实用的方法，该方法可用于药物合成中间体、液晶材料和光学分辨剂等多种用途，包括在过渡金属催化剂和光学活性含氮化合物或过渡金属催化剂与光学活性含氮化合物作为不对称配体以及供氢有机或无机化合物存在下进行氢转移型不对称还原。 根据本发明，外消旋仲醇或中型二元醇通过氢转移型氧化可回收光学活性仲醇。
• Amido thiazole derivatives as NADPH oxidase inhibitors
  申请人：GENKYOTEX SA

  公开号：EP3034500A1

  公开（公告）日：2016-06-22

  The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的氨基噻唑衍生物、其药物组合物及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的紊乱或病症的用途。
• BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES
  申请人：Syntex (U.S.A.) LLC

  公开号：EP0757677B1

  公开（公告）日：2003-06-18
• FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1144415A2

  公开（公告）日：2001-10-17