4,5-dihydro-3-methyl-1-(3,5-dimethylphenyl)-1H-benzo[d]azepin-2(3H)-one | 1428449-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 4,5-dihydro-3-methyl-1-(3,5-dimethylphenyl)-1H-benzo[d]azepin-2(3H)-one
• 英文别名: 5-(3,5-dimethylphenyl)-3-methyl-2,5-dihydro-1H-3-benzazepin-4-one
• CAS: 1428449-38-0
• 化学式: C₁₉H₂₁NO
• 分子量: 279.382
• InChiKey: HRBNFALAXAXZOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,5-二甲基溴苯 、 3-甲基-1,3,4,5-四氢苯并[D]氮杂螺-2-酮 在 copper(l) iodide 、 palladium diacetate 、 sodium hydride 、 三苯基膦 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以86%的产率得到4,5-dihydro-3-methyl-1-(3,5-dimethylphenyl)-1H-benzo[d]azepin-2(3H)-one
  参考文献：
  名称：

  Microwave assisted palladium catalyzed intermolecular α-arylation of copper-amide enolate of benzazepine

  摘要：

  Intermolecular alpha-arylation of copper enolate of 3-benzazepin-2-one with aryl halides in the presence of palladium as catalyst is reported as a general method. To the best of our knowledge this is the first Letter of the use of copper enolates of amides for C-C bond formation. The scope of the base, solvent, ligand, and catalysts used has also been investigated. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.02.026

文献信息

• Microwave assisted palladium catalyzed intermolecular α-arylation of copper-amide enolate of benzazepine
  作者：Amit Verma、Navneet Prajapati、Sujata Salecha、Rajani Giridhar、Mange Ram Yadav

  DOI：10.1016/j.tetlet.2013.02.026

  日期：2013.4

  Intermolecular alpha-arylation of copper enolate of 3-benzazepin-2-one with aryl halides in the presence of palladium as catalyst is reported as a general method. To the best of our knowledge this is the first Letter of the use of copper enolates of amides for C-C bond formation. The scope of the base, solvent, ligand, and catalysts used has also been investigated. (C) 2013 Elsevier Ltd. All rights reserved.