Di-(2-methyl-benzimidazol-5-yl)-methan | 1158-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Di-(2-methyl-benzimidazol-5-yl)-methan
• 英文别名: 2,2'-dimethyl-1(3)H,1'(3')H-5,5'-methanediyl-bis-benzoimidazole；2-Methyl-5-[(2-methyl-1H-1,3-benzodiazol-5-YL)methyl]-1H-1,3-benzodiazole；2-methyl-6-[(2-methyl-3H-benzimidazol-5-yl)methyl]-1H-benzimidazole
• CAS: 1158-07-2
• 化学式: C₁₇H₁₆N₄
• mdl: MFCD14712108
• 分子量: 276.341
• InChiKey: GYVRAJJKSFYCSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,4-亚甲基双(2-硝基苯胺) 在 盐酸 、 tin 作用下， 生成 Di-(2-methyl-benzimidazol-5-yl)-methan
  参考文献：
  名称：

  Meyer,J.; Rohmer, Chemische Berichte, 1900, vol. 33, p. 254

  摘要：

  DOI：

文献信息

• Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics
  作者：Syed Abuzar、Satyavan Sharma、Nigar Fatma、S. Gupta、P. K. Murthy、J. C. Katiyar、R. K. Chatterjee、A. B. Sen

  DOI：10.1021/jm00157a032

  日期：1986.7

  A series of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds have been synthesized of which 2,2'-bis(carbomethoxyamino)-5,5'-dibenzimidazolyl ketone exhibited a broad spectrum of anthelmintic activity in experimental animals. At doses of 10-50 mg/kg given intraperitoneally, 5 killed 100% of the adult worms of Litomosoides carinii, Dipetalonema viteae, and Brugia malayi. By the

  合成了一系列的2,2'-双取代的5,5'-二苯并咪唑基酮和相关化合物，其中2,2'-双（羰甲氧基氨基）-5,5'-二苯并咪唑基酮在实验中表现出广谱的驱虫活性动物。腹膜内注射剂量为10-50 mg / kg时，有5只可杀死100％的Cartoii Litomosoides，Dipetalonema viteae和Brugia malayi的成虫。通过口服途径，在100-200 mg / kg X 5天时，5的大杀线效率为97-100％。处理过的动物表现出微丝aria逐渐消失，在尸检前它们变成了微丝aria。某些化合物还以50-250 mg / kg的单次口服剂量对大鼠中的人钩虫和and虫，仓鼠中的Ancylostoma ceylanicum和Hymenolepis nana表现出100％的功效。
• LINKED DIBENZIMIDAZOLE ANTIVIRALS
  申请人：Qiu Yao-Ling

  公开号：US20100266543A1

  公开（公告）日：2010-10-21

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
• ANTI-VIRAL COMPOUNDS
  申请人：Krueger Allan C.

  公开号：US20140364616A1

  公开（公告）日：2014-12-11

  The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.
• US8039166B2
  申请人：——

  公开号：US8039166B2

  公开（公告）日：2011-10-18
• US8314135B2
  申请人：——

  公开号：US8314135B2

  公开（公告）日：2012-11-20