(E)-(2S,4R,5R,7R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4-dimethyl-9-phenyl-7-triisopropylsilanyloxy-non-8-ene-1,3-dione | 153402-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(2S,4R,5R,7R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4-dimethyl-9-phenyl-7-triisopropylsilanyloxy-non-8-ene-1,3-dione
• 英文别名: (E,2S,4R,5R,7R)-1-[(4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-5-hydroxy-2,4-dimethyl-9-phenyl-7-tri(propan-2-yl)silyloxynon-8-ene-1,3-dione
• CAS: 153402-93-8
• 化学式: C₃₆H₅₁NO₆Si
• 分子量: 621.89
• InChiKey: AAPRVFUPPRQHMY-KKDGIWQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.44
• 重原子数：
  44
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-(2S,4R,5R,7R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4-dimethyl-9-phenyl-7-triisopropylsilanyloxy-non-8-ene-1,3-dione 在 lithium hydroxide 、 zinc(II) tetrahydroborate 、 双氧水 、 氢气 、 臭氧 、 三苯基膦 作用下， 生成 (R)-3-((2R,3S,4R,5S)-4-Hydroxy-3,5-dimethyl-6-oxo-tetrahydro-pyran-2-yl)-2-triisopropylsilanyloxy-propionaldehyde
  参考文献：
  名称：

  The synthesis of a C1-C8 lactone fragment of discodermolide

  摘要：

  The assymetric synthesis of a fragment corresponding to the C-1-C-8 region of the immunosuppressant dicodermolide is reported. A trihydroxylactone of defined absolute stereochemistry is also prepared. This compound is a potential reductive ozonolysis product of discodermolide and may aid the determination of the absolute stereochemistry or the natural product

  DOI：

  10.1016/s0040-4039(00)61479-x
• 作为产物：
  描述：

  (E)-(R)-1-((S)-4-Isopropyl-2-thioxo-thiazolidin-3-yl)-5-phenyl-3-triisopropylsilanyloxy-pent-4-en-1-one 在 N,N-二乙基甲胺 、 氯代二环己基硼烷 、 二异丁基氢化铝 作用下， 生成 (E)-(2S,4R,5R,7R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4-dimethyl-9-phenyl-7-triisopropylsilanyloxy-non-8-ene-1,3-dione
  参考文献：
  名称：

  The synthesis of a C1-C8 lactone fragment of discodermolide

  摘要：

  The assymetric synthesis of a fragment corresponding to the C-1-C-8 region of the immunosuppressant dicodermolide is reported. A trihydroxylactone of defined absolute stereochemistry is also prepared. This compound is a potential reductive ozonolysis product of discodermolide and may aid the determination of the absolute stereochemistry or the natural product

  DOI：

  10.1016/s0040-4039(00)61479-x