4-tetrahydropyranyloxy-4'-trifluormethyltolan | 400608-34-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tetrahydropyranyloxy-4'-trifluormethyltolan
• 英文别名: 2-[4-[2-[4-(trifluoromethyl)phenyl]ethynyl]phenoxy]oxane
• CAS: 400608-34-6
• 化学式: C₂₀H₁₇F₃O₂
• 分子量: 346.349
• InChiKey: BOQLPBZPYNKCSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-tetrahydropyranyloxy-4'-trifluormethyltolan 在 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.0h， 以90%的产率得到4-((4-(trifluoromethyl)phenyl)ethynyl)phenol
  参考文献：
  名称：

  WO2008/157745

  摘要：

  公开号：
• 作为产物：
  描述：

  4-[(tetrahydro-2H-pyran-2-yl)oxy]iodobenzene 在 bis-triphenylphosphine-palladium(II) chloride 甲醇 、 potassium fluoride 、 copper(l) iodide 、 二异丙胺 作用下， 反应 6.0h， 生成 4-tetrahydropyranyloxy-4'-trifluormethyltolan
  参考文献：
  名称：

  WO2008/157745

  摘要：

  公开号：

文献信息

• Methods for treating subjects infected with a herpes virus or neisseria gonorrheae
  申请人：——

  公开号：US20020103262A1

  公开（公告）日：2002-08-01

  The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with Neisseria gonorrhea.

  本发明提供了一种抑制感染性疱疹病毒颗粒形成的方法，特别是在宿主细胞中抑制感染性单纯疱疹病毒（HSV）颗粒的方法。该方法涉及向感染疱疹病毒的宿主细胞中投入有效量的羟基化托兰，特别是多羟基化托兰。本发明还提供了一种治疗疱疹病毒感染，特别是HSV感染的方法。该方法包括向疱疹病毒感染部位投入含有治疗有效量羟基化托兰的局部组合物。本发明还涉及一种用于治疗疱疹病毒感染的局部组合物，所述感染可以是HSV感染、巨细胞病毒感染或水痘带状疱疹病毒感染。本发明还提供了一种治疗被淋病奈瑟氏菌感染的受试者的方法。
• Methods for treating subjects infected with herpes virus or Neisseria gonorrheae
  申请人：——

  公开号：US20030203974A1

  公开（公告）日：2003-10-30

  The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with Neisseria gonorrhea.

  本发明提供了一种抑制宿主细胞内感染性疱疹病毒颗粒形成的方法，特别是抑制感染性单纯疱疹病毒（HSV）颗粒形成的方法。该方法涉及向疱疹病毒感染的宿主细胞中投入有效量的羟基化甲苯，特别是多羟基化甲苯。本发明还提供了一种治疗疱疹病毒感染，特别是HSV感染的方法。该方法包括向疱疹病毒感染部位投入含有治疗有效量的羟基化甲苯的局部组合物。本发明还涉及一种用于治疗疱疹病毒感染的局部组合物，所述疱疹病毒感染包括HSV感染、巨细胞病毒感染和带状疱疹病毒感染。本发明还提供了一种治疗感染淋病奈瑟菌的受试者的方法。
• Methods for treating subjects infected with a herpes virus
  申请人：Northeastern Ohio Universities College of Medicine

  公开号：US06599945B2

  公开（公告）日：2003-07-29

  The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with Neisseria gonorrhea.

  本发明提供了一种抑制宿主细胞中感染性疱疹病毒颗粒，特别是感染性单纯疱疹病毒（HSV）颗粒形成的方法。该方法涉及向感染疱疹病毒的宿主细胞中施加有效量的羟基化甲苯，特别是多羟基化甲苯。本发明还提供了一种治疗疱疹病毒感染，特别是HSV感染的方法。该方法包括向疱疹病毒感染部位施加含有羟基化甲苯治疗剂量的局部组成物。本发明还涉及一种用于治疗疱疹病毒感染的局部组成物，所述疱疹病毒感染包括HSV感染、巨细胞病毒感染和水痘带状疱疹病毒感染。本发明还提供了一种治疗感染淋病奈瑟菌的受试者的方法。
• ASCORBATE, VITAMIN K3 AND HYDROXYTOLANS IN THE TREATMENT OF CANCER
  申请人：Tsai Chun-che

  公开号：US20110160301A1

  公开（公告）日：2011-06-30

  The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.

  羟基甲苯系列化合物与抗坏血酸加萘醌（维生素K3; VK3）或VK3的醌或半醌类似物的组合，可杀死肿瘤细胞，抑制肿瘤生长和发展，并治疗需要的患者的癌症。
• HYDROXYLATED TOLANS AND RELATED COMPOUNDS IN THE TREATMENT OF A CANCER
  申请人：Tsai Chun-Che

  公开号：US20110130468A1

  公开（公告）日：2011-06-02

  Compounds of the hydroxytolan family kill tumor cells, inhibit tumor growth and development, and are thus useful in method for treating a tumor or cancer in subjects in need thereof. These compounds are also active in preventing or treating a variety of skin diseases and conditions. The most preferred hydroxytolan compounds are 4,4′-dihydroxytolan. (KST-201), 4 hydroxy 4′ trifluoromethyltolan or 4′ hydroxy 4 trifluoromethyltolan (KST-213), 3,4′,5-trihydroxytolan or 3′,4,5′-trihydroxytolan (KST-301) and 3,3′,5,5′-tetrahydroxytolan (KST-401). The compounds and methods of using them alone and in combination with ascorbate and certain cyclic compounds to inhibit the development, growth or metastasis of tumor/cancer or preneoplastic cells, or to prevent or treat skin disorders in a subject are disclosed.

  羟基托兰家族的化合物可以杀死肿瘤细胞，抑制肿瘤的生长和发展，因此在治疗需要此类方法的患者的肿瘤或癌症中非常有用。这些化合物也可以预防或治疗各种皮肤疾病和状况。最受欢迎的羟基托兰化合物是4,4'-二羟基托兰（KST-201），4-羟基-4'-三氟甲基托兰或4'-羟基-4-三氟甲基托兰（KST-213），3,4'，5-三羟基托兰或3'，4，5'-三羟基托兰（KST-301）和3,3'，5,5'-四羟基托兰（KST-401）。本文揭示了使用这些化合物及其与抗坏血酸和某些环状化合物的组合物单独或联合使用的方法，以抑制肿瘤/癌症或癌前细胞的发展，生长或转移，或预防或治疗主体的皮肤疾病。