3α-hydroxy-11-oxo-5β-cholanoic acid-(24)-methyl ester | 111819-46-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α-hydroxy-11-oxo-5β-cholanoic acid-(24)-methyl ester
• 英文别名: 3α-Hydroxy-11-oxo-5β-cholansaeure-(24)-methylester；methyl (4R)-4-[(3R,5R,8S,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate
• CAS: 111819-46-6
• 化学式: C₂₅H₄₀O₄
• 分子量: 404.59
• InChiKey: XAAOVQCJMNBXLL-PPODUPMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3α-hydroxy-11-oxo-5β-cholanoic acid-(24)-methyl ester 在 吡啶 、 sodium hydroxide 、 乙醚 、 溶剂黄146 、 铂 作用下， 生成 3α-acetoxy-11β-hydroxy-5β-cholan-24-oic acid methyl ester
  参考文献：
  名称：

  Turner et al., Journal of Biological Chemistry, 1946, vol. 166, p. 345,357

  摘要：

  DOI：
• 作为产物：
  描述：

  12α-bromo-3α-hydroxy-11-oxo-5β-cholanoic acid-(24)-methyl ester 在 溶剂黄146 、 锌 作用下， 生成 3α-hydroxy-11-oxo-5β-cholanoic acid-(24)-methyl ester
  参考文献：
  名称：

  Turner et al., Journal of Biological Chemistry, 1946, vol. 166, p. 345,357

  摘要：

  DOI：

文献信息

• �ber Gallens�uren und verwandte Stoffe. 23. Mitteilung. Ester der 3,11-Diketo-cholans�ure, 3?-Oxy-11-keto-cholans�ure und 3?, 11?-Dioxy-cholans�ure
  作者：A. Lardon、T. Reichstein

  DOI：10.1002/hlca.19430260220

  日期：1943.3.15
• Lidocaine added to a tracheostomy tube cuff reduces tube discomfort
  作者：Waka Hirota、Wataru Kobayashi、Keiichi Igarashi、Yasuko Yagihashi、Hiroto Kimura、James Strupish、Kazuyoshi Hirota

  DOI：10.1007/bf03018969

  日期：2000.5

  Purpose: To examine whether lidocaine diffusion across an endotracheal tube cuff affects tracheostomy tube discomfort.Methods: Two tracheostomy tube cuffs were inflated with 5 mi lidocaine 4% solution and air at 20 cmH(2)O, and then placed in 20 mi distilled water at 37 degrees C. After vigorous stirring, 100 mu l of this water was then sampled immediately then 1, 2, 4, 8, 24 hr later to measure lidocaine concentration by high-performance liquid chromatography. Sixteen patients undergoing tracheostomy following oral cancer resection were randomly assigned to two groups: lidocaine (n=8) and placebo (n=8), A tracheostomy tube cuff was inflated with 5 mi lidocaine 4% or saline 0.9% and air to a cuff pressure of 20 cmH(2)O, in the lidocaine and placebo groups respectively, Tube discomfort was evaluated using a visual analogue scale at 0, 0.5, 1, 2 and 4 hr after lidocaine or saline administration, Neither analgesics nor sedatives was given during the evaluation period.Results: Lidocaine lime-dependently diffused across the tracheostomy tube cuff. Thirty and 60 min after cuff inflation lidocaine concentrations in the water bath reached approximately 8 and 17 mu g.ml(-1) representing 160 and 340 mu g in 20 ml of water, respectively. The VAS decreased from 53.5 +/- 10.6 to 25.1 +/- 9.8 mm (P < 0.01) 0.5 hr following lidocaine administration which continued until the end of evaluation period, in the placebo group, VAS did not change.Conclusion: Lidocaine diffusion across the tracheostomy tube cuff reduces tube discomfort.