2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-phenylacetamide | 1100612-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-phenylacetamide
• CAS: 1100612-27-8
• 化学式: C₂₀H₂₁NO₄
• 分子量: 339.391
• InChiKey: YOTKYEAXCJMNCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-phenylacetamide 、 3-溴丙炔 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 生成 N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-phenyl-2-prop-2-ynoxyacetamide
  参考文献：
  名称：

  Multicomponent reactions in fungicide research: The discovery of mandipropamid

  摘要：

  Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew). (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.019
• 作为产物：
  描述：

  苯甲醛 、 N-[2-(3-methoxy-4-(prop-2-ynyloxy)phenyl)ethyl]formamide 在 三光气 、 三乙胺 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 生成 2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-phenylacetamide
  参考文献：
  名称：

  Multicomponent reactions in fungicide research: The discovery of mandipropamid

  摘要：

  Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew). (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.019

文献信息

• Novel phenyl-propargylether derivatives
  申请人：Zeller Martin

  公开号：US20050026785A1

  公开（公告）日：2005-02-03

  The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R 1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R 2 and R 3 are each independently hydrogen or alkyl, R 4 is alkyl, alkenal or alkynyl, R 5 , R 6 , R 7 , and R 8 are each independently hydrogen or alkal, R 9 is hydrogen, optionally substituted alkyl, optionnaly substituted alkenyl or optionally substituted alkynyl, R 10 is optionally substituted aryl or optionaly substituted heteroaryl, and Z is optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy or optionally substituted alkynyloxy. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

  本发明涉及一般式I的苯基丙炔醚衍生物，包括其光学异构体和这些异构体的混合物，其中R1为氢、烷基、环烷基或可选取代芳基，R2和R3各自独立地为氢或烷基，R4为烷基、烯醛或炔基，R5、R6、R7和R8各自独立地为氢或烷基，R9为氢、可选取代烷基、可选取代烯基或可选取代炔基，R10为可选取代芳基或可选取代杂环芳基，Z为可选取代芳氧基、可选取代烷氧基、可选取代烯氧基或可选取代炔氧基。这些化合物具有有用的植物保护性能，可以优势地用于农业实践中控制或预防植物受到植物病原微生物，特别是真菌的侵害。
• NOVEL PHENYL-PROPARGYLETHER DERIVATIVES
  申请人：Syngenta Participations AG

  公开号：EP1444197A1

  公开（公告）日：2004-08-11
• [EN] NOVEL PHENYL-PROPARGYLETHER DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE PHENYL-PROPARGYLETHER
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2003041728A1

  公开（公告）日：2003-05-22

  The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenal or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkal, R9 is hydrogen, optionally substituted alkyl, optionnaly substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionaly substituted heteroaryl, and Z is optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy or optionally substituted alkynyloxy. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.
• Multicomponent reactions in fungicide research: The discovery of mandipropamid
  作者：Clemens Lamberth、Andre Jeanguenat、Fredrik Cederbaum、Alain De Mesmaeker、Martin Zeller、Hans-Joachim Kempf、Ronald Zeun

  DOI：10.1016/j.bmc.2007.10.019

  日期：2008.2.1

  Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew). (C) 2007 Elsevier Ltd. All rights reserved.