3-butenyltrimethylammonium bromide | 92303-55-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-butenyltrimethylammonium bromide
• 英文别名: but-3-enyl-trimethyl-ammonium; but-3-enyl-trimethyl-ammonium bromide；But-3-enyl(trimethyl)azanium;bromide
• CAS: 92303-55-4
• 化学式: Br*C₇H₁₆N
• 分子量: 194.115
• InChiKey: STBJYFDDRNDVKY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.73
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-butenyltrimethylammonium bromide 在 Amberlit IRA-400 、 potassium iodide 作用下， 以 水 为溶剂， 生成 碘化N,N,N-三甲基丁-3-烯-1-铵
  参考文献：
  名称：

  微观疏水性参数

  摘要：

  Le laurate de nitro-4 phenyle dans l'eau forme des agregats dans lesquels les groupesesters s'hydrolysent lentement。Desels, deformule generale RN(CH 3 ) 3 + X − rompent ou detruisent les agregats。Les groupesesters sont alors deproteges et les vitesses d'hydrolyse 观察羊角面包。L'importance de l'accroissement de vitesse depends de R

  DOI：

  10.1021/ja00271a029
• 作为产物：
  描述：

  4-溴-1-丁烯 、 三甲胺 以 甲醇 为溶剂， 生成 3-butenyltrimethylammonium bromide
  参考文献：
  名称：

  微观疏水性参数

  摘要：

  Le laurate de nitro-4 phenyle dans l'eau forme des agregats dans lesquels les groupesesters s'hydrolysent lentement。Desels, deformule generale RN(CH 3 ) 3 + X − rompent ou detruisent les agregats。Les groupesesters sont alors deproteges et les vitesses d'hydrolyse 观察羊角面包。L'importance de l'accroissement de vitesse depends de R

  DOI：

  10.1021/ja00271a029

文献信息

• Lukes; Trojanek, Collection of Czechoslovak Chemical Communications, 1951, vol. 16/17, p. 603,607
  作者：Lukes、Trojanek

  DOI：——

  日期：——
• Identifying inhibitors of intracellular protein fibrillization
  申请人：Kuret Jeff

  公开号：US20050153384A1

  公开（公告）日：2005-07-14

  Methods for identifying and characterizing inhibitors of protein filament formation are provided. These methods are particularly useful for identifying those agents which inhibit or prevent protein filament formation within neurons of mammalian subjects, particularly human subjects, such as the formation of tau filaments in Alzheimer's patients, and α-synuclein filaments in Parkinson's patients. According to the methods, protein monomers which are associated with formation of intra- or extra-cellular aggregates are combined under physiological conditions with a fibrillization inducer and the formation of protein aggregates is assessed in the absence and the presence of a test agent. The absence or a reduction in the size or stability of proteinaceous polymeric filaments as compared to a control indicates that the test agent is an inhibitor of proteinaceous polymeric filament formation.
• US7172875B2
  申请人：——

  公开号：US7172875B2

  公开（公告）日：2007-02-06
• [EN] IDENTIFYING INHIBITORS OF INTRACELLULAR PROTEIN FIBRILLIZATION<br/>[FR] IDENTIFICATION D'INHIBITEURS DE LA FIBRILLISATION PROTEIQUE INTRACELLULAIRE
  申请人：UNIV OHIO STATE RES FOUND

  公开号：WO2004073651A2

  公开（公告）日：2004-09-02

  Methods for identifying and characterizing inhibitors of protein filament formation are provided. These methods are particularly useful for identifying those agents which inhibit or prevent protein filament formation within neurons of mammalian subjects, particularly human subjects, such as the formation of tau filaments in Alzheimer's patients, and α-synuclein filaments in Parkinson's patients. According to the methods, protein monomers which are associated with formation of intra- or extra-cellular aggregates are combined under physiological conditions with a fibrillization inducer and the formation of protein aggregates is assessed in the absence and the presence of a test agent. The absence or a reduction in the size or stability of proteinaceous polymeric filaments as compared to a control indicates that the test agent is an inhibitor of proteinaceous polymeric filament formation.
• A microscopic hydrophobicity parameter
  作者：F. M. Menger、U. V. Venkataram

  DOI：10.1021/ja00271a029

  日期：1986.5

  Le laurate de nitro-4 phenyle dans l'eau forme des agregats dans lesquels les groupes esters s'hydrolysent lentement. Des sels, de formule generale RN(CH 3 ) 3 + X − rompent ou detruisent les agregats. Les groupes esters sont alors deproteges et les vitesses d'hydrolyse observees croissent. L'importance de l'accroissement de vitesse depend de R

  Le laurate de nitro-4 phenyle dans l'eau forme des agregats dans lesquels les groupesesters s'hydrolysent lentement。Desels, deformule generale RN(CH 3 ) 3 + X − rompent ou detruisent les agregats。Les groupesesters sont alors deproteges et les vitesses d'hydrolyse 观察羊角面包。L'importance de l'accroissement de vitesse depends de R