3-(3-hydroxypropyl)pyridine-5-carboxyaldehyde | 848397-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(3-hydroxypropyl)pyridine-5-carboxyaldehyde
• 英文别名: 5-(3-Hydroxypropyl)pyridine-3-carbaldehyde；5-(3-hydroxypropyl)pyridine-3-carbaldehyde
• CAS: 848397-30-8
• 化学式: C₉H₁₁NO₂
• 分子量: 165.192
• InChiKey: XLQPRTDWSOMCAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  13-amino-6,20-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione 、 3-(3-hydroxypropyl)pyridine-5-carboxyaldehyde 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 13.0h， 生成 2,10-dihydroxy-6-(((5-(3-hydroxypropyl)pyridin-3-yl)methylene)amino)-12-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
  参考文献：
  名称：

  NOVEL INDOLOPYRROLOCARBAZOLE DERIVATIVE WITH ANTITUMOR ACTIVITY

  摘要：

  本发明涉及一种新颖的吲哚吡咯咯嗪衍生物，其由以下式[I]表示：其中：A代表O、NH或CH2；R1代表单键、较低的烷基、较低的烯基、较低的炔基等；R2代表苯基、萘基或含有N、S或O中至少一个原子的五元或六元芳香或脂环，其中苯基、萘基、芳香或脂环可以被取代；G代表己糖基或戊糖基，或其药用可接受的盐。

  公开号：

  EP1666485A1

文献信息

• Novel indolopyrrolocarbazole derivative with antitumor activity
  申请人：Yamada Koji

  公开号：US20070042975A1

  公开（公告）日：2007-02-22

  The present invention relates to a novel indolopyrrolocarbazole derivative which is represented by the formula [I]: wherein: A represents O, NH, or CH 2 ; R 1 represents a single bond, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, etc.; R 2 represents a phenyl group, a naphthyl group, or a five- or six-membered aromatic or aliphatic heterocyclic ring having at least one atom selected from N, S, or O, wherein the phenyl group, naphthyl group, aromatic or aliphatic heterocyclic ring may be substituted; and G represents a hexose group or a pentose group, or a pharmaceutically acceptable salt thereof.
• NOVEL INDOLOPYRROLOCARBAZOLE DERIVATIVE WITH ANTITUMOR ACTIVITY
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1666485A1

  公开（公告）日：2006-06-07

  The present invention relates to a novel indolopyrrolocarbazole derivative which is represented by the formula [I]: wherein: A represents O, NH, or CH2; R1 represents a single bond, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, etc.; R2 represents a phenyl group, a naphthyl group, or a five- or six-membered aromatic or aliphatic heterocyclic ring having at least one atom selected from N, S, or O, wherein the phenyl group, naphthyl group, aromatic or aliphatic heterocyclic ring may be substituted; and G represents a hexose group or a pentose group, or a pharmaceutically acceptable salt thereof

  本发明涉及一种新颖的吲哚吡咯咯嗪衍生物，其由以下式[I]表示：其中：A代表O、NH或CH2；R1代表单键、较低的烷基、较低的烯基、较低的炔基等；R2代表苯基、萘基或含有N、S或O中至少一个原子的五元或六元芳香或脂环，其中苯基、萘基、芳香或脂环可以被取代；G代表己糖基或戊糖基，或其药用可接受的盐。