2-(4-tert-Butyl-phenyl)-1-(3-methoxy-propyl)-6-[(5-((3-methoxy-propyl)aminocarbonyl)-pentyl)oxy]-benzimidazole | 486418-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-tert-Butyl-phenyl)-1-(3-methoxy-propyl)-6-[(5-((3-methoxy-propyl)aminocarbonyl)-pentyl)oxy]-benzimidazole
• 英文别名: 2-(4-tert-Butyl-phenyl)-1-(3-methoxy-propyl)-6-[(5-((3-methoxy-propyl)amino-carbonyl)-pentyl)oxy]-benzimidazole；6-[2-(4-tert-butylphenyl)-3-(3-methoxypropyl)benzimidazol-5-yl]oxy-N-(3-methoxypropyl)hexanamide
• CAS: 486418-04-6
• 化学式: C₃₁H₄₅N₃O₄
• 分子量: 523.716
• InChiKey: ITKZDXQDKWVUOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(4-tert-Butyl-phenyl)-6-[(5-(methoxycarbonyl)pentyl)oxy]-1-(3-methoxy-propyl)-benzimidazole 、 3-甲氧基丙胺 以2-(4-tert-Butyl-phenyl)-1-(3-methoxy-propyl)-6-[(5-((3-methoxy-propyl)amino-carbonyl)-pentyl)oxy]-benzimidazole is obtained as a yellow solid的产率得到2-(4-tert-Butyl-phenyl)-1-(3-methoxy-propyl)-6-[(5-((3-methoxy-propyl)aminocarbonyl)-pentyl)oxy]-benzimidazole
  参考文献：
  名称：

  1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives

  摘要：

  本发明涉及一种具有一般式I的新型苯并咪唑衍生物，其中基团R1、R2、R3、A、B和Y具有说明书和权利要求中所示的含义，这些化合物用于制备用于治疗和预防与小胶质细胞激活相关的疾病的药物，以及含有这些化合物的制药制剂。

  公开号：

  US06855714B2

文献信息

• 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Schering AG

  公开号：US20030055057A1

  公开（公告）日：2003-03-20

  The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R 1 , R 2 , R 3 , A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds. 1

  该发明涉及一种具有一般式I的新型苯并咪唑衍生物，其中基团R1、R2、R3、A、B和Y具有说明书和权利要求所示的含义，这些化合物的用途是生产用于治疗和预防与微胶质细胞活化相关的疾病的药物剂，以及含有这些化合物的制药制剂。
• US6855714B2
  申请人：——

  公开号：US6855714B2

  公开（公告）日：2005-02-15
• 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US06855714B2

  公开（公告）日：2005-02-15

  The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R 1 , R 2 , R 3 , A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.

  本发明涉及一种具有一般式I的新型苯并咪唑衍生物，其中基团R1、R2、R3、A、B和Y具有说明书和权利要求中所示的含义，这些化合物用于制备用于治疗和预防与小胶质细胞激活相关的疾病的药物，以及含有这些化合物的制药制剂。