(6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-1,6,7,11b-tetrahydro-pyrido[2,1-a]isoquinolin-4-one | 909281-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-1,6,7,11b-tetrahydro-pyrido[2,1-a]isoquinolin-4-one
• 英文别名: (6S,11bR)-6-[[tert-butyl(diphenyl)silyl]oxymethyl]-9,10-dimethoxy-1,6,7,11b-tetrahydrobenzo[a]quinolizin-4-one
• CAS: 909281-69-2
• 化学式: C₃₂H₃₇NO₄Si
• 分子量: 527.736
• InChiKey: MOOMONQFLOQLHU-RBJSKKJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-1,6,7,11b-tetrahydro-pyrido[2,1-a]isoquinolin-4-one 、 1,3-二硫烷-2-甲酸乙酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 2-[(6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl]-[1,3]dithiolane-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets

  摘要：

  We report new and complementary routes for the highly stereoselective construction of functionalized benzoquinolizidine targets from readily available, non-racemic chiral templates. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure, and provide ready access to alternative stereoisomers. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.06.035
• 作为产物：
  描述：

  (6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-1,2,3,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-4-one 在 sodium periodate 、 碳酸氢钠 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 42.0h， 生成 (6S,11bR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9,10-dimethoxy-1,6,7,11b-tetrahydro-pyrido[2,1-a]isoquinolin-4-one
  参考文献：
  名称：

  Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets

  摘要：

  We report new and complementary routes for the highly stereoselective construction of functionalized benzoquinolizidine targets from readily available, non-racemic chiral templates. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure, and provide ready access to alternative stereoisomers. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.06.035

文献信息

• Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets
  作者：Steven M. Allin、Liam J. Duffy、Philip C. Bulman Page、Vickie McKee、Mark Edgar、Michael J. McKenzie、Mercedes Amat、Oriol Bassas、Maria M.M. Santos、Joan Bosch

  DOI：10.1016/j.tetlet.2006.06.035

  日期：2006.8

  We report new and complementary routes for the highly stereoselective construction of functionalized benzoquinolizidine targets from readily available, non-racemic chiral templates. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure, and provide ready access to alternative stereoisomers. (c) 2006 Elsevier Ltd. All rights reserved.