1-[(2'-hydroxy-3'-benzoyl)phenyl]prop-2-ene | 46874-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(2'-hydroxy-3'-benzoyl)phenyl]prop-2-ene
• 英文别名: allyl-2-hydroxybenzophenone；[2-Hydroxy-3-(prop-2-en-1-yl)phenyl](phenyl)methanone；(2-hydroxy-3-prop-2-enylphenyl)-phenylmethanone
• CAS: 46874-86-6
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: WHFYPKHIQTXNAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[(2'-hydroxy-3'-benzoyl)phenyl]prop-2-ene 、 三氟甲磺酸酐 在 palladium 10% on activated carbon N,N-二异丙基乙胺 、 盐酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.5h， 生成 1-[(2-trifluoromethanesulfonyloxy-3-benzoyl)phenyl]prop-2-ene
  参考文献：
  名称：

  [EN] 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] ACIDES 2-ARYLACETIQUES, LEURS DERIVES ET DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES

  摘要：

  公开号：

  WO2004069782A3
• 作为产物：
  描述：

  2-羟基二苯甲酮 以75%的产率得到1-[(2'-hydroxy-3'-benzoyl)phenyl]prop-2-ene
  参考文献：
  名称：

  [EN] 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] ACIDES 2-ARYLACETIQUES, LEURS DERIVES ET DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES

  摘要：

  公开号：

  WO2004069782A3

文献信息

• [EN] COMPOUNDS FOR OPTICALLY ACTIVE DEVICES<br/>[FR] COMPOSÉS POUR DISPOSITIFS OPTIQUEMENT ACTIFS
  申请人：MERCK PATENT GMBH

  公开号：WO2020212543A1

  公开（公告）日：2020-10-22

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices.

  本发明涉及包含光活性单元的聚合化合物的创新眼科设备，所述聚合化合物，以及特别适合用于组合物和眼科设备的特殊单体化合物。
• Ocular devices manufactured with free radical-polymerizable latent ultra-violet absorbers
  申请人：JOHNSON & JOHNSON VISION PRODUCTS, INC.

  公开号：EP1584952A1

  公开（公告）日：2005-10-12

  The invention provides compositions for forming ocular devices which compositions contain latent UV absorbers. The compositions of the invention may be used to conveniently and efficiently produce ocular devices through UV initiated, free radical polymerization.

  该发明提供了含有潜在紫外线吸收剂的形成眼部装置的组合物。该发明的组合物可用于通过紫外线引发的自由基聚合方便高效地生产眼部装置。
• [EN] AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES<br/>[FR] DÉRIVÉS D'AZACOUMARINES ET D'AZATHIOCOUMARINE DESTINÉS À ÊTRE UTILISÉS DANS DES DISPOSITIFS OPTIQUEMENT ACTIFS
  申请人：MERCK PATENT GMBH

  公开号：WO2021233800A1

  公开（公告）日：2021-11-25

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive chromophore, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices. The present invention is also directed to a process of changing the optical properties of said ophthalmic device or a precursor article for manufacturing said ophthalmic device.

  本发明涉及包括聚合物化合物的新型眼科器件，所述聚合物化合物包括光活性色素，以及特殊单体化合物，特别适用于眼科器件的组合物和眼科器件。本发明还涉及一种改变所述眼科器件的光学性能或用于制造所述眼科器件的前体物品的方法。
• 2-Aryl-acetic acids, their derivatives and pharmaceutical compositions containing them
  申请人：Moriconi Alessio

  公开号：US20060223842A1

  公开（公告）日：2006-10-05

  Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2-membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

  选择的2-芳基乙酸及其衍生物和包含这些化合物的药物组合物对于抑制由白细胞介素-8（IL-8）与CXCR1和CXCR2膜受体相互作用引起的嗜中性粒细胞（PMN白细胞）趋化活化非常有用。这些化合物用于预防和治疗由该活化引起的病理。特别是2（邻）-取代芳基乙酸或其衍生物，例如酰胺和磺酰胺，缺乏环氧合酶抑制活性，特别适用于治疗嗜中性粒细胞依赖性病理，如银屑病、溃疡性结肠炎、黑色素瘤、慢性阻塞性肺疾病（COPD）、大疱性类天疱疮、类风湿性关节炎、特发性纤维化、肾小球肾炎以及缺血再灌注引起的损伤的预防和治疗。
• PREPOLYMERS SUITABLE FOR MAKING ULTRA-VIOLET ABSORBING CONTACT LENSES
  申请人：Domschke Angelika Maria

  公开号：US20110063567A1

  公开（公告）日：2011-03-17

  The invention provides a class of actinically-crosslinkable silicone-containing prepolymers which comprise (1) ethylenically-unsaturated groups and (2) UV-absorbing polymeric units, latent UV-absorbing polymeric units, and/or dual photo-functional polymeric units. The prepolymer of the invention can be used to prepare silicone hydrogel contact lenses capable of absorbing UV/visible radiation. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.

  本发明提供一类光致交联硅含量预聚物，其包括（1）乙烯基-不饱和基团和（2）紫外线吸收聚合物单元、潜在紫外线吸收聚合物单元和/或双重光功能聚合物单元。本发明的预聚物可用于制备能够吸收紫外线/可见光辐射的硅水凝胶隐形眼镜。本发明还涉及使用本发明预聚物制造硅水凝胶隐形眼镜的方法，以成本效益高、一致性高和对原始镜片设计的高度忠实。