2-methylene-6,6-diphenyltetrahydro-1H-pyrrolizin-3(2H)-one | 1296204-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methylene-6,6-diphenyltetrahydro-1H-pyrrolizin-3(2H)-one
• 英文别名: 2-Methylidene-6,6-diphenyl-1,5,7,8-tetrahydropyrrolizin-3-one
• CAS: 1296204-69-7
• 化学式: C₂₀H₁₉NO
• 分子量: 289.377
• InChiKey: WAWITXWMFHGOCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-diphenyl-4-pentenylamine 在 吡啶 、 (M,3aS,3a'S)-3,3',3a',4,4',5,5'-octahydro-3,3,3',3'-tetraisopropyl-6,6'-spirobi[6H-cyclopent[c]isoxazole] 、 palladium(II) trifluoroacetate 、 氧气 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 50.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 生成 2-methylene-6,6-diphenyltetrahydro-1H-pyrrolizin-3(2H)-one
  参考文献：
  名称：

  Pd(II)-SPRIX catalyzed enantioselective construction of pyrrolizines/pyrroloindoles employing molecular oxygen as the sole oxidant

  摘要：

  Pd(II)-SPRIX catalyst coupled with an environmentally benign molecular oxygen as the sole oxidant successfully exploited the construction of pyrrolizines/pyrroloindoles, imperative scaffolds of bio-potent molecules through intramolecular C-N and C-C bond forming reactions in good yields with appreciable enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.02.057

文献信息

• Palladium-Catalyzed Aerobic Oxidative Cyclization of Aliphatic Alkenyl Amides for the Construction of Pyrrolizidine and Indolizidine Derivatives
  作者：Dan Yang、Kai-Yip Lo、Liu Ye

  DOI：10.1055/s-0036-1588502

  日期：2017.8

  An efficient palladium-catalyzed aerobic oxidative cyclization has been developed to synthesize a variety of pyrrolizidine and indolizidine derivatives from simple aliphatic alkenyl amides in moderate to good yields. The reaction features the capability of accessing various N-heterocycles and the use of molecular oxygen (1 atm) as the green oxidant.

  已经开发出一种有效的钯催化的有氧氧化环化反应，以中等至良好的产率从简单的脂肪族烯基酰胺合成各种吡咯里西啶和吲哚里西啶衍生物。该反应具有访问各种 N-杂环的能力和使用分子氧 (1 atm) 作为绿色氧化剂的能力。
• Pd(II)-SPRIX catalyzed enantioselective construction of pyrrolizines/pyrroloindoles employing molecular oxygen as the sole oxidant
  作者：Chennan Ramalingan、Kazuhiro Takenaka、Hiroaki Sasai

  DOI：10.1016/j.tet.2011.02.057

  日期：2011.4

  Pd(II)-SPRIX catalyst coupled with an environmentally benign molecular oxygen as the sole oxidant successfully exploited the construction of pyrrolizines/pyrroloindoles, imperative scaffolds of bio-potent molecules through intramolecular C-N and C-C bond forming reactions in good yields with appreciable enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.