2-乙基-1,3-二甲氧基-5-甲基苯 | 32551-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙基-1,3-二甲氧基-5-甲基苯
• 英文名称: 2-ethyl-1,3-dimethoxy-5-methylbenzene
• CAS: 32551-62-5
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: KBHCITMKIJKTSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-乙基-1,3-二甲氧基-5-甲基苯 在 正丁基锂 、 溴 作用下， 以 四氯化碳 为溶剂， 反应 2.5h， 生成 3-ethyl-2,4-dimethoxy-6-methylbenzoic acid
  参考文献：
  名称：

  O-Methylasparvenone, a nitrogen-free serotonin antagonist

  摘要：

  O-Methylasparvenone (1) and asparvenone (2) were isolated from an Aspergillus parvulus Smith broth in a microbial screening for 5-HT2C ligands and found to be 5-HT2C antagonists. They represent the first nitrogen-free serotonin ligands. The absolute configuration of 1 was determined to be S by X-ray analysis of the corresponding Mosher-ester. A short and efficient synthesis of rac-1 was developed. This protocol was applied to the synthesis of derivatives of 1 and a structure-affinity relationship was established. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00160-0
• 作为产物：
  描述：

  3,5-二甲氧基甲苯 、 碘乙烷 生成 2-乙基-1,3-二甲氧基-5-甲基苯
  参考文献：
  名称：

  VIJKNA, A. X.;MIKKAL, M. D.;EHJNBORN, I. R., TR. TALLIN. POLITEXN. IN-TA, 1983, N 543, 73-83

  摘要：

  DOI：

文献信息

• New Drug Delivery System for Crossing the Blood Brain Barrier
  申请人：Lipshutz H. Bruce

  公开号：US20070203080A1

  公开（公告）日：2007-08-30

  New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

  新的泛醌类似物被披露，以及利用这些化合物将药物基团输送到人体的方法。
• UBIQUINONE ANALOGS AND METHODS OF USE
  申请人：Lipshutz H. Bruce

  公开号：US20070208086A1

  公开（公告）日：2007-09-06

  New ubiquinone and ubiquinol analogs are disclosed, as well as methods of making and using these compounds.

  本发明揭示了新的泛醌和泛醌醇类似物，以及制备和使用这些化合物的方法。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Hadida Ruah Sara S.

  公开号：US20130237568A1

  公开（公告）日：2013-09-12

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• RAPID CURE POLYMERIC RESINS
  申请人：THE BOEING COMPANY

  公开号：US20160177000A1

  公开（公告）日：2016-06-23

  A polysulfide material having reactive vinyl end groups and a method of making a vinyl end-capped polysulfide material are described. The vinyl end-capped polysulfide material has potential applications as a sealant, an adhesive, a coating, a caulking, or the like. In a specific example, the polysulfide material may be used as a precursor material for a sealant resin in the manufacturing of an integral fuel tank of an aircraft. An example method for making polysulfide materials includes contacting a vinyl-functionalized aryl halide and/or a vinyl-functionalized heteroaryl halide with dithiols and/or trithiols in the presence of an organic solvent.
• INTRODUCTION OF ALKYL SUBSTITUENTS TO AROMATIC COMPOUNDS
  申请人：B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY

  公开号：US20180065904A1

  公开（公告）日：2018-03-08

  Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.