2-amino-4-bromo-6-ethoxycarbonylpyridine | 865604-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-bromo-6-ethoxycarbonylpyridine
• 英文别名: ethyl 6-amino-4-bromopicolinate；ethyl 2-amino-4-bromopyridine-6-carboxylate；ethyl 6-amino-4-bromopyridine-2-carboxylate
• CAS: 865604-39-3
• 化学式: C₈H₉BrN₂O₂
• 分子量: 245.076
• InChiKey: MMTDUJJBMARVGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氯乙醛 、 2-amino-4-bromo-6-ethoxycarbonylpyridine 以 乙醇 、 水 为溶剂， 反应 3.0h， 以87%的产率得到ethyl 7-bromoimidazo[1,2-a]pyridine-5-carboxylate
  参考文献：
  名称：

  5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

  摘要：

  Dual inhibitors of bacterial gyrB and parE based on a 5-(2-pyrimidinyl)-imidazo[1,2-a]pyridine template exhibited MICs (mu g/mL) of 0.06-64 (Sau), 0.25-64 (MRSA), 0.06-64 (Spy), 0.06-64 (Spn), and 0.03-64 (FQR Spn). Selected examples were efficacious in mouse sepsis and lung infection models at <50 mg/kg (PO dosing). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.141

文献信息

• [EN] IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES D'IMIDAZOPYRIDINE ET D'IMIDAZOPYRIMIDINE EN TANT QU'AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2005089763A1

  公开（公告）日：2005-09-29

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  公开了式I的化合物及其制备方法。进一步公开了制备式I生物活性化合物的方法，以及包含式I化合物的药用可接受组合物的方法。本文公开的式I化合物可用于各种应用，包括用作抗菌剂。
• IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Sciotti Richard John

  公开号：US20090275577A1

  公开（公告）日：2009-11-05

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了化学式I的化合物及其制备方法。还披露了制备具有生物活性的化学式I化合物的方法，以及包含化学式I化合物的药学可接受组合物的方法。本文所披露的化学式I的化合物可用于多种应用，包括用作抗菌剂。
• Antibacterial agents
  申请人：Sciotti Richard John

  公开号：US20070191394A1

  公开（公告）日：2007-08-16

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文公开了化学式I的化合物及其制备方法。此外，还公开了制备生物活性化合物的方法，这些生物活性化合物的化学式为I，并且公开了包含化学式I化合物的药学上可接受的组合物的制备方法。本文所公开的化学式I的化合物可以在多种应用中使用，包括用作抗菌剂。
• Antibacterial Agents
  申请人：Butler Charles Donnell David

  公开号：US20080021059A1

  公开（公告）日：2008-01-24

  The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.

  本发明涉及一种新型的三唑吡啶衍生物，其用作抗微生物药物，以及含有这些化合物的药物。
• [EN] TRIAZOLOPYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2006038116A3

  公开（公告）日：2006-07-13