1-[(4-Chlorophenyl)methyl]-2-(piperidin-1-ylmethyl)benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-[(4-Chlorophenyl)methyl]-2-(piperidin-1-ylmethyl)benzimidazole
• 化学式: C₂₀H₂₂ClN₃
• 分子量: 339.868
• InChiKey: ZJXYCPYKTLURDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌啶 、 1-(4-氯苄基)-1H-苯并咪唑-2-甲醛 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 生成 1-[(4-Chlorophenyl)methyl]-2-(piperidin-1-ylmethyl)benzimidazole
  参考文献：
  名称：

  [EN] METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
  [FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE L'ÉPILEPSIE

  摘要：

  提供了治疗癫痫的方法和组合物。在一个方面，本文提供了一种选择治疗癫痫化合物的方法，该方法包括将测试化合物与5-羟色胺-2B受体（5-HT2B）接触，并测量测试化合物的5-HT2B激动活性。在另一个方面，本文提供了一种治疗患有癫痫的受试者的方法。该方法包括向该受试者施用有效量的5-HT2B特异性受体激动剂。

  公开号：

  WO2020243349A1

文献信息

• Methods and compositions of treating a flaviviridae family viral infection
  申请人：Einav Shirit

  公开号：US20100028299A1

  公开（公告）日：2010-02-04

  Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

  简要描述，本公开涉及的实施例包括化合物、制药组合物、治疗感染黄病毒科病毒的宿主的方法、抑制宿主中HCV复制的方法、抑制NS4B多肽与HCV负链RNA的3'UTR结合的方法、治疗宿主肝纤维化的方法等。
• METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
  申请人：Choong Ingrid C.

  公开号：US20120276050A1

  公开（公告）日：2012-11-01

  Clemizole and clemizole analog compounds, and pharmaceutical compositions of the same, are useful in methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, and methods of treating liver fibrosis in a host.
• US8975247B2
  申请人：——

  公开号：US8975247B2

  公开（公告）日：2015-03-10
• [EN] METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION<br/>[FR] MÉTHODES ET COMPOSITIONS POUR TRAITER L'INFECTION PAR UN VIRUS DE LA FAMILLE DES FLAVIVIRIDAE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2010107739A2

  公开（公告）日：2010-09-23

  Clemizole and clemizole analog compounds, and pharmaceutical compositions of the same, are useful in methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, and methods of treating liver fibrosis in a host.
• [EN] METHODS AND COMPOSITIONS FOR TREATING EPILEPSY<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE L'ÉPILEPSIE
  申请人：UNIV CALIFORNIA

  公开号：WO2020243349A1

  公开（公告）日：2020-12-03

  Provided, inter alia, are methods and compositions for treating epilepsy. In one aspect, provided herein is a method of selecting a compound for treating epilepsy, said method includes, contacting a test compound with 5-hydroxytryptamine-2B receptor (5-HT2B), and measuring the 5-HT2B agonistic activity of the test compound. In another aspect, provided herein is a method of treating an epilepsy in a subject in need thereof. The method includes administering to said subject an effective amount of a 5-HT2B specific receptor agonist.

  提供了治疗癫痫的方法和组合物。在一个方面，本文提供了一种选择治疗癫痫化合物的方法，该方法包括将测试化合物与5-羟色胺-2B受体（5-HT2B）接触，并测量测试化合物的5-HT2B激动活性。在另一个方面，本文提供了一种治疗患有癫痫的受试者的方法。该方法包括向该受试者施用有效量的5-HT2B特异性受体激动剂。