2-imino-5,5-pentamethylene-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide | 1202751-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-imino-5,5-pentamethylene-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide
• CAS: 1202751-58-3
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.369
• InChiKey: UEGBUASMBQIBLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.19
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.17
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-imino-5,5-pentamethylene-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide 在 盐酸 作用下， 以 苯 为溶剂， 以98%的产率得到2-imino-5,5-pentamethylene-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082
• 作为产物：
  描述：

  2-imino-3-carbamoyl-4-methyl-5,5-pentamethylene-2,5-dihydrofuran 、 苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以85%的产率得到2-imino-5,5-pentamethylene-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082