2-(bromomethyl)-5-(difluoromethyl)furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(bromomethyl)-5-(difluoromethyl)furan
• 英文别名: 2-(Bromomethyl)-5-(difluoromethyl)furan
• 化学式: C₆H₅BrF₂O
• 分子量: 211.006
• InChiKey: GNJGABUDJGDBGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-乙酰氧基甲基-2-呋喃醛 在 二乙胺基三氟化硫 、 水 、 三溴化磷 、 lithium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 2-(bromomethyl)-5-(difluoromethyl)furan
  参考文献：
  名称：

  [EN] HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME
  [FR] COMPOSÉS HÉTÉROARYLIQUES POUVANT ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE L'ENZYME SAE

  摘要：

  公开号：

  WO2015002994A3

文献信息

• Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
  申请人：K.U.Leuven Research & Development

  公开号：EP2161273A1

  公开（公告）日：2010-03-10

  The present invention relates to pharmaceutical compositions for the treatment or prevention of vital infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (A): wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及用于治疗或预防重要感染的药物组合物，其活性成分包括至少一种具有通式（A）的咪唑并[4,5-c]吡啶原药： 其中取代基见说明书。 本发明还涉及根据本发明制备和筛选具有上述通式的化合物的工艺及其在治疗或预防病毒感染中的用途。
• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP3016934B1

  公开（公告）日：2018-01-10
• HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：US20160355504A1

  公开（公告）日：2016-12-08

  Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra′, Rc, Rf, X2, Rd, Rd′, Re, Re′2, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
• US9695154B2
  申请人：——

  公开号：US9695154B2

  公开（公告）日：2017-07-04
• [EN] HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME<br/>[FR] COMPOSÉS HÉTÉROARYLIQUES POUVANT ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE L'ENZYME SAE
  申请人：MILLENNIUM PHARM INC

  公开号：WO2015002994A2

  公开（公告）日：2015-01-08

  Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.