2-(11-hydroxy-11-methyldodecyl)isoindole-1,3-dione | 869093-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(11-hydroxy-11-methyldodecyl)isoindole-1,3-dione
• 英文别名: N-(11-hydroxy-11-methyldodecyl) phthalimide；2-(11-Hydroxy-11-methyldodecyl)-1H-isoindole-1,3(2H)-dione
• CAS: 869093-92-5
• 化学式: C₂₁H₃₁NO₃
• 分子量: 345.482
• InChiKey: NYSBGWRGOFFZNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(11-hydroxy-11-methyldodecyl)isoindole-1,3-dione 在 silver perchlorate 、 一水合肼 作用下， 以 甲醇 、 硝基甲烷 为溶剂， 反应 3.0h， 生成 11-isocyano-11-methyl dodecylamine
  参考文献：
  名称：

  Design and synthesis of anti-barnacle active fluorescence-labeled probe compounds and direct observation of the target region in barnacle cypris larvae for dimethyl-isocyanoalkyl compounds

  摘要：

  Anti-barnacle active fluorescence-labeled probe compounds were synthesized, and the interaction between the synthesized probe compounds and the cypris larvae of barnacles was observed under a fluorescence microscope. The observation suggests that anti-fouling active isocyano substances would express activity by acting on the oil cell area in barnacle cypris larvae. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.024
• 作为产物：
  描述：

  12-溴-2-甲基-2-十二烷醇 、 potassium phtalimide 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以2.4 g的产率得到2-(11-hydroxy-11-methyldodecyl)isoindole-1,3-dione
  参考文献：
  名称：

  Design and synthesis of anti-barnacle active fluorescence-labeled probe compounds and direct observation of the target region in barnacle cypris larvae for dimethyl-isocyanoalkyl compounds

  摘要：

  Anti-barnacle active fluorescence-labeled probe compounds were synthesized, and the interaction between the synthesized probe compounds and the cypris larvae of barnacles was observed under a fluorescence microscope. The observation suggests that anti-fouling active isocyano substances would express activity by acting on the oil cell area in barnacle cypris larvae. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.024

文献信息

• One-Pot Synthesis of Isocyanides from Alcohols
  作者：Yoshikazu Kitano、Iku Okada

  DOI：10.1055/s-0031-1289592

  日期：2011.12

  A one-pot reaction of alcohols with trimethylsilyl cyanide and methanesulfonic acid with subsequent neutralization by triethylamine and dehydration by tosyl chloride and pyridine gave the corresponding isocyanides in moderate-to-high yields. This method was used to synthesize tertiary and benzylic isocyanides from the corresponding alcohols. isocyanides - alcohols - Ritter reactions

  醇与三甲基甲硅烷基氰化物和甲磺酸的一锅反应，随后通过三乙胺中和，并通过甲苯磺酰氯和吡啶进行脱水，以中等至高收率得到了相应的异氰化物。该方法用于从相应的醇合成叔和苄基异氰化物。 异氰化物-醇-里特反应
• Direct Synthesis of Bis(alkylamino)maleonitriles from Alcohols and TMSCN with Bi(OTf)3
  作者：Yoshikazu Kitano、Iku Okada、Takuya Fukuda、Yu Kuroda、Keiichi Noguchi、Kazuhiro Chiba

  DOI：10.1055/s-0036-1588661

  日期：——

  a single step from tertiary alcohols. A direct method for preparing bis(alkylamino)maleonitriles from alcohols was developed. Treatment of tertiary alcohols with trimethylsilyl cyanide (TMSCN) and trimethylsilyl triflate (TMSOTf) in the presence of bismuth(III) triflate [Bi(OTf)3] afforded the corresponding bis(alkylamino)maleonitriles in moderate-to-high yields. Tertiary alcohols with various functional

  摘要 开发了由醇制备双（烷基氨基）马来腈的直接方法。在三氟甲磺酸铋（III）[Bi（OTf）3 ]存在下，用氰化三甲基甲硅烷基氰（TMSCN）和三氟甲磺酸三甲基硅烷基酯（TMSOTf）处理叔醇，可得到中等至高收率的相应双（烷基氨基）马来腈。在这些条件下可以耐受具有各种官能团（例如卤素，醚，酯和酰亚胺官能团）的叔醇。这是从叔醇一步制备双（烷基氨基）马来腈的合成方法的首次报道。 开发了由醇制备双（烷基氨基）马来腈的直接方法。在三氟甲磺酸铋（III）[Bi（OTf）3 ]存在下，用氰化三甲基甲硅烷基氰（TMSCN）和三氟甲磺酸三甲基硅烷基酯（TMSOTf）处理叔醇，可得到中等至高收率的相应双（烷基氨基）马来腈。在这些条件下可以耐受具有各种官能团（例如卤素，醚，酯和酰亚胺官能团）的叔醇。这是从叔醇一步制备双（烷基氨基）马来腈的合成方法的首次报道。
• Novel Isonitrile Compound, Its Method Of Manufacture, A Marine Fouling Organism Larva Fluorescent, And A Method Of Detecting This Marine Fouling Organism Larva Using Said Marker
  申请人：Kitano Yoshikazu

  公开号：US20080299674A1

  公开（公告）日：2008-12-04

  Novel isonitrile compounds represented by the general formula F-A-NC, their method of manufacture, a marine fouling organism larva fluorescent marker having at least one of these compounds as an active ingredient, and a method of detecting this marine fouling organism larva using this marker. F in the aforesaid general formula represents a fluorescent functional group, and A represents a linking chain.

  小说是以一般公式F-A-NC表示的异腈化合物，它们的制造方法，具有至少一种这些化合物作为活性成分的海洋污垢生物幼虫荧光标记剂，以及使用该标记剂检测该海洋污垢生物幼虫的方法。上述一般公式中，F代表荧光功能基团，而A代表连接链。
• NOVEL ISONITRILE COMPOUND, PROCESS FOR PRODUCING THE SAME, FLUORESCENCE LABELING AGENT FOR MARINE ATTACHED ORGANISM LARVA CONTAINING THE COMPOUND, AND METHOD OF DETECTING MARINE ATTACHED ORGANISM LARVA THEREWITH
  申请人：National University Corporation Tokyo University of Agriculture and Technology

  公开号：EP1783177A1

  公开（公告）日：2007-05-09

  Novel isonitrile compounds represented by the general formula F-A-NC, their method of manufacture, a marine fouling organism larva fluorescent marker having at least one of these compounds as an active ingredient, and a method of detecting this marine fouling organism larva using this marker. F in the aforesaid general formula represents a fluorescent functional group, and A represents a linking chain.

  通式F-A-NC所代表的新型异腈化合物、其制造方法、至少以其中一种化合物为有效成分的海洋污损生物幼虫荧光标记物，以及使用该标记物检测该海洋污损生物幼虫的方法。 上述通式中的 F 代表荧光官能团，A 代表连接链。
• EP1783177
  申请人：——

  公开号：——

  公开（公告）日：——