N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)benzamide | 131423-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)benzamide
• 英文别名: N-(5-methoxy-[1,3]thiazolo[5,4-b]pyridin-2-yl)benzamide
• CAS: 131423-85-3
• 化学式: C₁₄H₁₁N₃O₂S
• 分子量: 285.326
• InChiKey: GHTITGJUYYCKLL-UHFFFAOYSA-N

物化性质

• 熔点：
  215 °C
• 密度：
  1.410±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)benzamide 在 sodium azide 、 五氯化磷 、 sodium acetate 作用下， 以 水 、 丙酮 为溶剂， 反应 13.0h， 生成 5-Methoxy-2-(5-phenyltetrazol-1-yl)-[1,3]thiazolo[5,4-b]pyridine
  参考文献：
  名称：

  Prasad, V.S.R.; Sambaiah, T.; Reddy, K. Kondal, Synthetic Communications, 1990, vol. 20, # 13, p. 1983 - 1988

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯-2-氨基噻唑[5,4-B]并吡啶 、 苯甲酰氯 在 吡啶 作用下， 反应 2.0h， 以85%的产率得到N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)benzamide
  参考文献：
  名称：

  Prasad, V.S.R.; Sambaiah, T.; Reddy, K. Kondal, Synthetic Communications, 1990, vol. 20, # 13, p. 1983 - 1988

  摘要：

  DOI：

文献信息

• [EN] BENZOTHIAZOLE AND THIAZOLE'5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS<br/>[FR] COMPOSITIONS DE BENZOTHIAZOLE ET DE THIAZOLE'5,5-B!PYRIDINE ET LEUR UTILISATION COMME INHIBITEURS DE L'UBIQUITINE LIGASE
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2005037845A1

  公开（公告）日：2005-04-28

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  这项发明描述了化合物和制药组合物，作为泛素代理抑制剂。该发明的化合物和制药组合物作为抑制泛素化参与的生物化学途径的抑制剂是有用的。该发明还包括使用该发明的化合物和制药组合物治疗需要抑制泛素化的情况。此外，该发明还包括通过使用该发明的制药组合物接触需要抑制泛素化的细胞来抑制细胞内泛素化的方法。
• Benzothiazole compositions and their use as ubiquitin ligase inhibitors
  申请人：Ramesh V. Usha

  公开号：US20050130974A1

  公开（公告）日：2005-06-16

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  本发明描述了化合物和药物组合物，可用作泛素代理抑制剂。本发明的化合物和药物组合物可用作生物体中涉及泛素化的生化途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物治疗需要抑制泛素化的疾病的方法。此外，本发明还包括通过将本发明的药物组合物接触到需要抑制泛素化的细胞中来抑制细胞泛素化的方法。
• Benzothniazole compositions and their use as ubiquition ligation inhibitors
  申请人：Ramesh V. Usha

  公开号：US20080039629A1

  公开（公告）日：2008-02-14

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  本发明描述了化合物和药物组合物，作为泛素剂抑制剂。本发明的化合物和药物组合物可用作生物体中泛素化参与的生化途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物治疗需要抑制泛素化的疾病的方法。此外，本发明还包括抑制细胞中泛素化的方法，其中包括将需要抑制泛素化的细胞与本发明的药物组合物接触。
• PRASAD, V. S. R.;SAMBAIAH, T.;REDDY, K. KONDAL, SYNTH. COMMUN., 20,(1990) N3, C. 1983-1988
  作者：PRASAD, V. S. R.、SAMBAIAH, T.、REDDY, K. KONDAL

  DOI：——

  日期：——
• BENZOTHIAZOLE AND THIAZOLE'5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP1680431A1

  公开（公告）日：2006-07-19