3,3-dihydroperoxy-1,5-(bisphenyl)pentane | 1374458-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-dihydroperoxy-1,5-(bisphenyl)pentane
• 英文别名: (3,3-Dihydroperoxy-5-phenylpentyl)benzene
• CAS: 1374458-49-7
• 化学式: C₁₇H₂₀O₄
• 分子量: 288.343
• InChiKey: CWHBCKYRBLAPAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,5-二苯基-3-戊酮 、 3,3-dihydroperoxy-1,5-(bisphenyl)pentane 在 双氧水 作用下， 以 三氟乙醇 为溶剂， 反应 24.0h， 以22%的产率得到3,3,6,6-tetra(phenethyl)-1,2,4,5-tetraoxan
  参考文献：
  名称：

  Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives

  摘要：

  Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.

  DOI：

  10.1111/j.1747-0285.2012.01345.x
• 作为产物：
  描述：

  1,5-二苯基-3-戊酮 在 盐酸 、 双氧水 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 24.0h， 以84%的产率得到3,3-dihydroperoxy-1,5-(bisphenyl)pentane
  参考文献：
  名称：

  Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives

  摘要：

  Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.

  DOI：

  10.1111/j.1747-0285.2012.01345.x

文献信息

• Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
  作者：Lucas Lopardi Franco、Mauro Vieira de Almeida、Luiz Francisco Rocha e Silva、Pedro Paulo Ribeiro Vieira、Adrian Martin Pohlit、Marcelo Siqueira Valle

  DOI：10.1111/j.1747-0285.2012.01345.x

  日期：2012.5

  Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.