2-fluoro-N-methylpyridine p-toluenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-N-methylpyridine p-toluenesulfonate
• 英文别名: 2-fluoro-1-methyl-2H-pyridine;4-methylbenzenesulfonic acid
• 化学式: C₆H₈FN*C₇H₈O₃S
• 分子量: 285.339
• InChiKey: AMGZELLFFNISNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-fluoro-N-methylpyridine p-toluenesulfonate 、 N-(叔丁氧羰基)抑胃酶氨酸 、 苯酚 在 三正丁胺 作用下， 以 二氯甲烷 为溶剂， 生成 phenyl 4(S)-t-butoxycarbonylamino-3(S)-hydroxy-6-methylheptanoate
  参考文献：
  名称：

  New renin-inhibitory peptides and their use

  摘要：

  式为R.sup.1 CO--NH--CH(R.sup.2)--CONH--CH(R.sup.3)--X的化合物【其中：R.sup.1代表具有α-氨基或保护的α-氨基取代基和芳基、杂环基或杂环二硫基的烷基；R.sup.2代表多种脂肪和环脂烃基，可能被取代；R.sup.3代表异丁基、仲丁基、苄基或（C.sub.3 -C.sub.8环烷基）甲基；X代表式--CH(--A--R.sup.4)--Y的基团（其中：A代表单键或烷基基团；R.sup.4代表羧基、保护的羧基、氨基甲酰基、N-取代氨基甲酰基、氨基苯并噻唑基、N-取代氨基苯并噻唑基或酰基；Y代表羟基、巯基或甲酰基），或式--P(O) (R.sup.5)--OH的基团（其中R.sup.5代表取代的烷基基团，至少有一个取代基被选择自羧基、保护的羧基、N-取代氨基甲酰基、氨基苯并噻唑基、N-取代氨基苯并噻唑基、C.sub.2 -C.sub.7脂肪羧酰基和芳香族羧酰基）】及其盐是肾素抑制剂，可用于治疗由肾素引起的高血压。

  公开号：

  US04698329A1

文献信息

• General method for the covalent immobilisation of indicators in, or onto a support useful for the fabrication of optical sensors
  申请人：Innosense S.r.l.

  公开号：EP1213583A1

  公开（公告）日：2002-06-12

  The invention discloses a method for the covalent immobilisation of indicator dyes in, or onto a support. The dyes can work in absorbance, reflectance or fluorescence mode. The dyed support is useful as the transducer element in an optical sensor. According to the invention, Figure 1, the indicator dye is dissolved or suspended in a solvent medium, optionally containing electrolytes to control ionic strength and pH. Aqueous formaldehyde is then added to the mixture. A support to be used as the sensing element in an optical sensor is added to the mixture and stirred or shaken for a period of time at a temperature comprised between room temperature and 100°C. Suitable supports include inorganic and organic polymers with primary and/or secondary amino groups.

  本发明公开了一种将指示剂染料共价固定在支持物中或支持物上的方法。这些染料可以在吸光、反射或荧光模式下工作。染色支撑物可用作光学传感器中的换能器元件。根据本发明，如图 1 所示，指示剂染料溶解或悬浮在溶剂介质中，可选择含有电解质以控制离子强度和 pH 值。然后向混合物中加入甲醛水溶液。将用作光学传感器传感元件的支撑物加入混合物中，并在室温至 100°C 之间的温度下搅拌或振荡一段时间。合适的支撑物包括带有伯氨基和/或仲氨基的无机和有机聚合物。
• CONDUCTIVE POLYMER FILM, ELECTRONIC DEVICE, AND METHODS OF PRODUCING THE FILM AND THE DEVICE
  申请人：HARADA Gaku

  公开号：US20100232090A1

  公开（公告）日：2010-09-16

  To provide a conductive polymer film and to improve the conductivity of the conductive polymer film used in an electronic device such as a solid electrolytic capacitor, the conductive polymer film is a conductive polymer film formed by using a polymerization liquid containing a monomer for a conductive polymer, an oxidant, and an additive. A salt formed of a dopant and a basic substance is used as the additive.
• SOLID ELECTROLYTIC CAPACITOR AND FABRICATION METHOD THEREOF
  申请人：ISHIKAWA Toru

  公开号：US20100271757A1

  公开（公告）日：2010-10-28

  To provide a solid electrolytic capacitor having a high capacitance and an excellent heat resistance. A solid electrolytic capacitor includes: an anode 2 ; a dielectric layer 3 provided on the surface of the anode 2 ; a first conductive polymer layer 4 a provided on the dielectric layer 3 ; a second conductive polymer layer 4 b provided on the first conductive polymer layer 4 a ; a third conductive polymer layer 4 c provided on the second conductive polymer layer 4 b ; and a cathode layer provided on the third conductive polymer layer 4 c , wherein the first conductive polymer layer 4 a is made of a conductive polymer film formed by polymerizing pyrrole or a derivative thereof, the second conductive polymer layer 4 b is made of a conductive polymer film formed by polymerizing thiophene or a derivative thereof, and the third conductive polymer layer 4 c is made of a conductive polymer film formed by electropolymerizing pyrrole or a derivative thereof.
• CONDUCTIVE POLYMER FILM, ELECTRIC DEVICES AND METHODS FOR MANUFACTURING THE CONDUCTIVE POLYMER FILM
  申请人：SANO Takeshi

  公开号：US20120049136A1

  公开（公告）日：2012-03-01

  Conductive polymer films are provided having excellent conductivity. Electronic devices made from the films and manufacturing methods of the conductive polymer film also are provided. The conductive polymer films are obtained from polymerization liquid that includes monomers of a conductive polymer, an oxidizer, an alcoholic solvent, and an aromatic solvent contained in the polymerization liquid in the proportion of 1 to 50 percent by mass of the total solvent for polymerization. The aromatic solvent contains, as a substituent group of an aromatic ring, an alkyl group with a carbon number of 1 to 10 and/or an alkoxy group with a carbon number of 1 to 10, but lacks a hydroxyl group.
• US4698329A
  申请人：——

  公开号：US4698329A

  公开（公告）日：1987-10-06