N-(3,4-difluorophenyl)pyridin-2-amine | 666258-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-difluorophenyl)pyridin-2-amine
• 英文别名: 3,4-F2(anilinopyridine)
• CAS: 666258-99-7
• 化学式: C₁₁H₈F₂N₂
• mdl: MFCD24391192
• 分子量: 206.195
• InChiKey: BKMAAZNXLXUOOC-UHFFFAOYSA-N

物化性质

• 沸点：
  285.6±35.0 °C(Predicted)
• 密度：
  1.312±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3,4-difluorophenyl)pyridin-2-amine 、 3,4-二氟溴苄 以 乙腈 为溶剂， 反应 12.0h， 生成 [1-(3,4-difluorobenzyl)-1H-pyridin-2-ylidene]-(3,4-difluorophenyl)amine
  参考文献：
  名称：

  WO2008/58537

  摘要：

  公开号：
• 作为产物：
  描述：

  N-(3,4-difluorophenyl)-N-pyridin-2-ylformamide 在 sodium hydroxide 作用下， 以 乙二醇二甲醚 为溶剂， 生成 N-(3,4-difluorophenyl)pyridin-2-amine
  参考文献：
  名称：

  WO2008/58537

  摘要：

  公开号：

文献信息

• Copper anchored on phosphorus g-C₃N₄ as a highly efficient photocatalyst for the synthesis of <i>N</i>-arylpyridin-2-amines
  作者：Jia-Qi Di、Mo Zhang、Yu-Xuan Chen、Jin-Xin Wang、Shan-Shan Geng、Jia-Qi Tang、Zhan-Hui Zhang

  DOI：10.1039/d0gc03400b

  日期：——

  A copper modified phosphorus doped g-C₃N₄ (Cu/P-CN) has been prepared and identified as an efficient catalyst for the synthesis of N-arylpyridin-2-amine derivatives by the reaction of 2-aminopyridine and aryl boronic acid under the irradiation of blue light.

  一种经过铜改性的磷掺杂的g-C3N4（Cu/P-CN）已经制备并确定为一种高效催化剂，可用于在蓝光照射下通过2-氨基吡啶和芳基硼酸的反应合成N-芳基吡啶-2-胺衍生物。
• NOVEL 2-AMINIO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Sorensen Ulrik Svane

  公开号：US20100056584A1

  公开（公告）日：2010-03-04

  This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及一种新型2-氨基吡啶衍生物，可用作小电导钙激活钾通道（SK通道）的调节剂。在其他方面，本发明涉及使用这些化合物的方法用于治疗，并涉及包含本发明化合物的药物组合物。
• Electrochemical and Spectroelectrochemical Characterization of Ru₂⁴⁺ and Ru₂³⁺ Complexes under a CO Atmosphere
  作者：Karl M. Kadish、Tuan D. Phan、Lingamallu Giribabu、Jianguo Shao、Li-Lun Wang、Antoine Thuriere、Eric Van Caemelbecke、John L. Bear

  DOI：10.1021/ic035026g

  日期：2004.2.1

  Eleven different Ru-2(4+) and Ru-2(3+) derivatives are characterized by thin-layer FTIR and UV-visible spectroelectrochemistry under a CO atmosphere. These compounds, which were in-situ electrogenerated from substituted anilinopyridine complexes with a Ru-2(5+) core, are represented as Ru-2(L)(4)Cl where L = 2-CH(3)ap, ap, 2-Fap, 2,3-F(2)ap, 2,4-F(2)ap, 2,5-F(2)ap, 3,4-F(2)ap, 3,5-F(2)ap, 2,4,6-F(3)ap, or F(5)ap. The Ru-2(5+) complexes do not axially bind CO while mono- and bis-CO axial adducts are formed for the Ru-2(4+) and Ru-2(3+) derivatives, respectively. Six of the eleven investigated compounds exist in a (4,0) isomeric form while five adopt a (3,1) geometric conformation. These two series of compounds thus provide a large enough number of derivatives to examine trends and differences in the spectroscopic data of the two types of isomers in their lower Ru-2(4+) and Ru-2(3+) oxidation states. UV-visible spectra of the Ru-2(4+) derivatives and IR spectra of the Ru-2(3+) complexes under CO are both isomer dependent, thus suggesting that these data can be used to reliably predict the isomeric form, i.e., (3,1) or (4,0), of diruthenium complexes containing four unsymmetrical substituted anilinopyridinate bridging ligands; this was confirmed by X-ray crystallographic data for seven compounds whose structures were available.
• US8039632B2
  申请人：——

  公开号：US8039632B2

  公开（公告）日：2011-10-18
• [EN] NOVEL 2-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS DE 2-AMINO-PYRIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DU CANAL POTASSIUM
  申请人：NEUROSEARCH AS

  公开号：WO2008058537A1

  公开（公告）日：2008-05-22

  [EN] This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
  [FR] Cette invention concerne de nouveaux dérivés de 2-amino-pyridine, utiles en tant que modulateurs des canaux potassium activés par le calcium de faible conductance (canaux SK). D'autres aspects de l'invention concernent l'utilisation de ces composés dans un procédé thérapeutique et des compositions pharmaceutiques comprenant les composés selon l'invention.