2,6-dimethoxy-4-hydroxyaniline | 20032-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-dimethoxy-4-hydroxyaniline
• 英文别名: 4-Amino-3,5-dimethoxyphenol
• CAS: 20032-71-7
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: NCJAKCZENDBSCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,6-dimethoxy-4-hydroxyaniline 在 copper(l) chloride 作用下， 生成 2,6-二甲氧基-1,4-苯醌
  参考文献：
  名称：

  Grove et al., Journal of the Chemical Society, 1952, p. 3949,3957

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-dimethoxy-4-nitrosophenol 在 ammonium hydroxide 、 硫化氢 作用下， 生成 2,6-dimethoxy-4-hydroxyaniline
  参考文献：
  名称：

  Grove et al., Journal of the Chemical Society, 1952, p. 3949,3957

  摘要：

  DOI：

文献信息

• Optimization of the Azobenzene Scaffold for Reductive Cleavage by Dithionite; Development of an Azobenzene Cleavable Linker for Proteomic Applications
  作者：Geoffray Leriche、Ghyslain Budin、Laurent Brino、Alain Wagner

  DOI：10.1002/ejoc.201000546

  日期：——

  henylazo)benzoic acid (HAZA) scaffold, the orthogonally protected difunctional azo–arene cleavable linker 26 was designed and synthesized. Selective linker deprotection and derivatization was performed by introducing an alkyne reactive group and a biotin affinity tag. This optimized azo–arene cleavable linker led to a total cleavage in less than 10 s with only 1 mM dithionite. Similar results were

  在本文中，我们进行了广泛的反应性研究，以确定有利于连二亚硫酸盐引发的偶氮芳烃基团还原裂解的关键结构特征。我们的逐步研究允许鉴定在缺电子芳烃的邻位带有羧酸的高反应性偶氮芳烃结构 25 和作为富电子芳烃的邻位-O-烷基间苯二酚。基于这种 2-(2'-烷氧基-4'-羟基苯基偶氮)苯甲酸 (HAZA) 支架，设计并合成了正交保护的双功能偶氮芳烃可裂解接头 26。通过引入炔反应基团和生物素亲和标签来进行选择性接头脱保护和衍生化。这种优化的偶氮芳烃可裂解接头导致在不到 10 秒内完全裂解，仅含 1 mM 连二亚硫酸盐。
• Synthesis of derivatives of benzene-1,2,3,5-tetrol
  作者：Emmanuel M. Kampouris

  DOI：10.1039/j39680002125

  日期：——

  1,3-Di-O-substituted derivatives of benzene-1,2,3,5-tetrol were prepared from 2-nitrophloroglucinol-1,3-dibenzenesulphonate, or other 1,3-di-O-substituted derivatives of 2-nitropholoroglucinol and 5-nitropyrogallol. The p-nitrophenols were reduced to the corresponding amines which were then oxidised by an improved method to the p-benzoquinones; these on reduction gave the products. The 1,3- and 2,5-dimethyl

  1,3-二- ö取代由2- nitrophloroglucinol -1,3- dibenzenesulphonate制备苯-1,2,3,5-四醇的衍生物，或其它的1,3-二- Ö取代的2-衍生物硝基邻苯三酚和5-硝基邻苯三酚。所述p -nitrophenols被还原成相应的胺，其随后通过一种改进的方法，以所述氧化的p -benzoquinones; 这些减少给了产品。还已经制备了四醇的1，3-和2，5-二甲基醚，2，3，5-三甲基醚和四甲基醚。
• 6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions
  申请人：Szucova Lucie

  公开号：US20090170879A1

  公开（公告）日：2009-07-02

  Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

  提供了某些6,9-二取代嘌呤衍生物及其药学上可接受的盐。这些6,9-二取代嘌呤衍生物及其药学上可接受的盐在组合物中对于治疗哺乳动物细胞，尤其是人类皮肤细胞，以缓解衰老的不良影响，治疗皮肤疾病状态，治疗由炎症引起或与之相关的免疫反应等方面非常有用。
• 6, 9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions
  申请人：Szucova Lucie

  公开号：US20110230503A1

  公开（公告）日：2011-09-22

  Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

  提供了某些6,9-二取代嘌呤衍生物及其药学上可接受的盐。这些6,9-二取代嘌呤衍生物及其药学上可接受的盐在组合物中用于治疗哺乳动物细胞，特别是人类皮肤细胞，以改善衰老的不良影响，治疗皮肤疾病状态，治疗由炎症引起或与之相关的免疫反应等。
• Weidel; Pollak, Monatshefte fur Chemie, 1900, vol. 21, p. 31
  作者：Weidel、Pollak

  DOI：——

  日期：——