1-((2-chloropyridin-5-yl)methyl)-8-nitro-2,3-dihydroimidazo[1,2-a]pyridine-5(1H)-one | 121071-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-((2-chloropyridin-5-yl)methyl)-8-nitro-2,3-dihydroimidazo[1,2-a]pyridine-5(1H)-one
• 英文别名: 1,2,3,5-tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a] pyridin-5-one；1,2,3,5-Tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one；1-[(6-chloropyridin-3-yl)methyl]-8-nitro-2,3-dihydroimidazo[1,2-a]pyridin-5-one
• CAS: 121071-84-9
• 化学式: C₁₃H₁₁ClN₄O₃
• 分子量: 306.708
• InChiKey: IRAXGVQNWSYZBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  82.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-5-氯甲基吡啶 在 氯化亚砜 、 potassium carbonate 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 1-((2-chloropyridin-5-yl)methyl)-8-nitro-2,3-dihydroimidazo[1,2-a]pyridine-5(1H)-one
  参考文献：
  名称：

  咪唑并吡啶类化合物及其中间体、制备方法与 应用

  摘要：

  本发明公开了式(I)所示的咪唑并吡啶类化合物及其制备方法与应用，式中各取代基具有说明书中所给定义。本发明式(I)化合物具有杀虫和杀菌生物活性，尤其是对害虫如蚜虫、飞虱等具有高活性，可用于防治蚜虫、飞虱和菌核病等虫害和病害。本发明的技术方案还包括一种制备式(I)化合物的中间体，该中间体的结构如通式(II)所示，式中各取代基的定义见说明书。

  公开号：

  CN111662283B

文献信息

• Pesticidal nitro-substituted heterocyclic compounds
  申请人：Nihon Tokushu Noyaku Seizo K.K.

  公开号：US04876263A1

  公开（公告）日：1989-10-24

  Nitro-subsliluted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally subtituted heterocyclic groun containing at least one atom selected from N, O and S, A is optionally substituted ethylene or optionally substituted trimethylene, and B stands for 2 or 3 members of a heterocyclic ring which is formed, together with the adjacent C-atom and N-aom and at least one of said members may represent a hetero atom and may be optionally substituted, provided that when B stands for 3 members, two of which are carbon atoms and the other one is a nitrogen atom which is located in the middle of the three members, then at least one of said two carbon atoms must be substituted by a keto group. Such compounds being useful as insecticides.

  式(I)的氮代取代杂环化合物，其中R是氢或烷基，Z是可选取代的芳基或含有至少一个选自N、O和S的原子的可选取代的杂环基，A是可选取代的乙烯或可选取代的三甲基乙烯，B代表由异杂环环组成的2或3个成员，其中与相邻的C原子和N原子一起形成，且至少一个成员可以表示一个杂原子并且可以是可选取代的，但当B代表3个成员时，其中2个是碳原子，另一个是位于三个成员中间的氮原子，则至少其中的一个碳原子必须被酮基取代。这些化合物可用作杀虫剂。
• Nitro-substituted heterocyclic compounds
  申请人：Nihon Bayer Agrochem K.K.

  公开号：US05622956A1

  公开（公告）日：1997-04-22

  Nitro-substituted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally substituted heterocyclic group containing at least one atom selected from N, O and S, A is optionally substituted ethylene or optionally substituted trimethylene, and B stands for 2 or 3 members of a heterocyclic ring which is formed, together with the adjacent C-atom and N-atom and at least one of said members may represent a hetero atom and may be optionally substituted, provided that when B stands for 3 members, two of which are carbon atoms and the other one is a nitrogen atom which is located in the middle of the three members, then at least one of said two carbon atoms must be substituted by a keto group. Such compounds being useful as insecticides.

  式(I)中的氮代取代杂环化合物：##STR1##其中R为氢或烷基，Z为可选取代的含有N、O和S中至少一个原子的芳基或杂环基团，A为可选取代的乙烯或可选取代的三甲基乙烯，B代表一个杂环环的2或3个成员，该环与相邻的C原子和N原子形成，其中至少一个成员可以表示为杂原子，且可以是可选取代的，但当B代表3个成员时，其中两个为碳原子，另一个为位于三个成员中间的氮原子，则其中至少一个碳原子必须被酮基取代。这些化合物可用作杀虫剂。
• Insectidal nitro-hydroimidazo[1,2-a] pyridines
  申请人：Nihon Tokushu Noyaku Seizo K. K.

  公开号：US04960780A1

  公开（公告）日：1990-10-02

  Nitro-substituted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally substituted heterocyclic groun containing at least one atom selected from N, O and S, A is optionally substituted ethylene or optionally substituted trimethylene, and B stands for 2 or 3 members of a heterocyclic ring which is formed, together with the adjacent C-atom and N-atom and at least one of said members may represent a hetero atom and may be optionally substituted, provided that when B stands for 3 members, two of which are carbon atoms and the other one is a nitrogen atom which is located in the middle of the three members, then at least one of said two carbon atoms must be substituted by a keto group. Such compounds being useful as insecticides.

  化学式为（I）的取代硝基杂环化合物，其中R为氢或烷基，Z为可选取代的芳基或含有至少一个N、O和S原子的可选取代杂环基团，A为可选取代的乙烯或可选取代的三亚甲基，B代表由异环环成的2或3个成员，其中与相邻的C原子和N原子一起形成，至少一个成员可能代表一个杂原子并且可以选择性地被取代，前提是当B代表3个成员时，其中有两个成员为碳原子，另一个成员为位于三个成员中间的氮原子，那么至少其中一个碳原子必须被酮基取代。这些化合物可用作杀虫剂。
• Insecticidal nitro-substituted heterocyclic compounds
  申请人：Nihon Bayer Agrochem K.K.

  公开号：US05231098A1

  公开（公告）日：1993-07-27

  Nitro-substituted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally substituted heterocyclic groun containing at least one atom selected from N, O and S, A is optionally substituted ethylene or optionally substituted trimethylene, and B stands for 2 or 3 members of a heterocyclic ring which is formed, together with the adjacent C-atom and N-atom and at least one of said members may represent a hetero atom and may be optionally substituted, provided that when B stands for 3 members, two of which are carbon atoms and the other one is a nitrogen atom which is located in the middle of the three members, then at least one of said two carbon atoms must be substituted by a keto group. Such compounds being useful as insecticides.

  式(I)中，R为氢或烷基，Z为可选取官能团取代的芳基或含有至少一个N、O、S原子的可选取官能团取代的杂环基，A为可选取官能团取代的乙烯基或三甲基乙烯基，B代表一个杂环环的2或3个成员，该环与相邻的C原子和N原子一起形成，至少一个成员可表示为杂原子并可选取取代，但当B代表3个成员时，其中两个是碳原子，另一个是位于三个成员中间的氮原子，则至少一个碳原子必须被酮基取代。这些化合物可用作杀虫剂。
• Insectidical nitro-substituted heterocyclic compounds
  申请人：Nihon Tokushu Noyaku Seizo K. K.

  公开号：US05036082A1

  公开（公告）日：1991-07-30

  Nitro-substituted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally substituted heterocyclic group containing at least one atom selected from N, O and S, A is optionally substituted ethylene or optionally substituted trimethylene, and B stands for 2 or 3 members of a heterocyclic ring which is formed, together with the adjacent C-atom and N-atom and at least one of said members may represent a hetero atom and may be optionally substituted, provided that when B stands for 3 members, two of which are carbon atoms and the other one is a nitrogen atom which is located in the middle of the three members, then at least one of said two carbon atoms must be substituted by a keto group. Such compounds being useful as insecticides.

  式（I）的亚硝基取代杂环化合物 ##STR1## 其中R为氢或烷基，Z为可选取代的含有至少一种N、O和S原子的芳基或杂环基，A为可选取代的乙烯或可选取代的三甲基乙烯，B代表异环戊二烯环的2或3个成员，该环与相邻的C原子和N原子形成，其中至少一个成员可能代表一个杂原子并且可以进行可选取代，但当B代表3个成员时，其中两个是碳原子，另一个是位于三个成员中间的氮原子，则至少其中一个碳原子必须被酮基取代。这些化合物可用作杀虫剂。