(S)-4-苄基-3-((苄氧基)甲基)吗啉 | 101376-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (S)-4-苄基-3-((苄氧基)甲基)吗啉
• 英文名称: (S)-4-benzyl-3-<(benzyloxy)methyl>morpholine
• 英文别名: (3S)-4-benzyl-3-(phenylmethoxymethyl)morpholine
• CAS: 101376-21-0
• 化学式: C₁₉H₂₃NO₂
• 分子量: 297.397
• InChiKey: MCKSMSMUMNSGDR-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-4-苄基-3-((苄氧基)甲基)吗啉 在 氢氧化钾 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 32.0h， 生成 (S)-3-<(benzyloxy)methyl>morpholine
  参考文献：
  名称：

  (S)-3-[(Benzyloxy)methyl]morpholine Hydrochloride: A Nonstimulant Appetite Suppressant without Conventional Neurotransmitter Releasing Properties

  摘要：

  The synthesis and appetite-suppressant activity of (S)-3-[(benzyloxy)methyl]morpholine hydrochloride in dogs are reported. The oral ED50 for appetite suppression in dogs of 3 was 12 mg/kg, and it was tolerated up to 200 mg/kg. 3 had no inhibitory effect on the release or uptake of noradrenaline, dopamine, or serotonin at 10(-5) M. The (R) enantiomer of 3 was not anorexiant.

  DOI：

  10.1021/jm00157a601
• 作为产物：
  描述：

  氯化苄 、 3(S)-羟基甲基-4-苄基吗啉 在 sodium hydride 作用下， 生成 (S)-4-苄基-3-((苄氧基)甲基)吗啉
  参考文献：
  名称：

  (S)-3-[(Benzyloxy)methyl]morpholine Hydrochloride: A Nonstimulant Appetite Suppressant without Conventional Neurotransmitter Releasing Properties

  摘要：

  The synthesis and appetite-suppressant activity of (S)-3-[(benzyloxy)methyl]morpholine hydrochloride in dogs are reported. The oral ED50 for appetite suppression in dogs of 3 was 12 mg/kg, and it was tolerated up to 200 mg/kg. 3 had no inhibitory effect on the release or uptake of noradrenaline, dopamine, or serotonin at 10(-5) M. The (R) enantiomer of 3 was not anorexiant.

  DOI：

  10.1021/jm00157a601

文献信息

• (S)-3-[(Benzyloxy)methyl]morpholine Hydrochloride: A Nonstimulant Appetite Suppressant without Conventional Neurotransmitter Releasing Properties
  作者：George Brown、Alan Foubister、Gillian Forster、Donald Stribling

  DOI：10.1021/jm00157a601

  日期：1986.7

  The synthesis and appetite-suppressant activity of (S)-3-[(benzyloxy)methyl]morpholine hydrochloride in dogs are reported. The oral ED50 for appetite suppression in dogs of 3 was 12 mg/kg, and it was tolerated up to 200 mg/kg. 3 had no inhibitory effect on the release or uptake of noradrenaline, dopamine, or serotonin at 10(-5) M. The (R) enantiomer of 3 was not anorexiant.