(3-Methyl-1,4-dioxonaphthalen-2-yl)methyl-triphenylphosphanium;chloride | 475633-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Methyl-1,4-dioxonaphthalen-2-yl)methyl-triphenylphosphanium;chloride
• CAS: 475633-16-0
• 化学式: C₃₀H₂₄O₂P*Cl
• 分子量: 482.946
• InChiKey: NSXZAOFXPKMOGE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-chloromethyl-3-methyl-1,4-naphthoquinone 、 三苯基膦 反应 0.5h， 生成 (3-Methyl-1,4-dioxonaphthalen-2-yl)methyl-triphenylphosphanium;chloride
  参考文献：
  名称：

  Phosphonium lipocations as antiparasitic agents

  摘要：

  Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low mu M concentrations against T. cruzi. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.02.045