alterporriol D | 119644-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: alterporriol D
• 英文别名: Alterporriol D/E；Alterporriol E；(1S,2R,3S,4R)-1,2,3,4,8-pentahydroxy-6-methoxy-3-methyl-5-[(5S,6R,7S,8R)-4,5,6,7,8-pentahydroxy-2-methoxy-7-methyl-9,10-dioxo-6,8-dihydro-5H-anthracen-1-yl]-2,4-dihydro-1H-anthracene-9,10-dione
• CAS: 119644-07-4；119718-06-8
• 化学式: C₃₂H₃₀O₁₆
• 分子量: 670.581
• InChiKey: IXBPWSPJMNOFJJ-KNEUHGCLSA-N

物化性质

• 沸点：
  1022.0±65.0 °C(Predicted)
• 密度：
  1.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  48
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  289
• 氢给体数：
  10
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  alterporriol D 在 sodium hydroxide 、 sodium dithionite 作用下， 以 水 为溶剂， 反应 2.0h， 生成 交替酚A
  参考文献：
  名称：

  Suemitsu, Rikisaku; Sakurai, Yoshiaki; Nakachi, Kenji, Agricultural and Biological Chemistry, 1989, vol. 53, # 5, p. 1301 - 1304

  摘要：

  DOI：

文献信息

• Absolute stereochemistry of altersolanol a and alterporriols
  作者：Saki Kanamaru、Miho Honma、Takanori Murakami、Taro Tsushima、Shinji Kudo、Kazuaki Tanaka、Ken-Ichi Nihei、Tatsuo Nehira、Masaru Hashimoto

  DOI：10.1002/chir.21035

  日期：2012.2

  The absolute stereochemistry of altersolanol A (1) was established by observing a positive exciton couplet in the circular dichroism (CD) spectrum of the C3,C4‐O‐bis(2‐naphthoyl) derivative 10 and by chemical correlations with known compound 8. Before the discussion, the relative stereochemistry of 1 was confirmed by X‐ray crystallographic analysis. The shielding effect at C7′‐OMe group by C1‐O‐benzoylation

  通过观察C3，C4 - O-双-（2-萘甲酰基）衍生物10的圆二色性（CD）光谱中的正激子对以及与已知化合物8的化学相关性，建立了交替酚A（1）的绝对立体化学。在讨论之前，X射线晶体学分析证实了1的相对立体化学。通过C1- O-苯甲酰化作用对C7'-OMe基团的屏蔽作用建立了C8-C8'轴向键合与阻转异构体戊二酚E（3）的C1-C4 / C1'-C4'多元醇部分之间的相对立体化学关系C8-C8'二聚体1的摩尔数。作为3可以通过体外1的二聚获得，其中心手性元素（C1-C4）的绝对构型必须与1相同。实验和理论CD光谱之间的光谱比较支持上述结论。通过比较它们的CD光谱与2和3的CD光谱，还揭示了新型C4- O-脱氧二聚体衍生物，卟啉酚F（4）和G（5）的轴向立体化学。手性，2012年。©2011 Wiley Periodicals，Inc.。
• TOMM6-INTERACTING EXTRACTS AND COMPOUNDS FOR USE IN THE TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISEASES, ATHEROSCLEROSIS, HEPATITIS B INFECTION AND HUMAN PAPILLOMA VIRUS (HPV) INFECTION
  申请人：ETH ZURICH

  公开号：US20210186947A1

  公开（公告）日：2021-06-24

  The present invention is directed to a TOMM6 (Translocase of Outer Membrane 6 kDa subunit homologue; Mitochondrial import receptor subunit TOM6 homolog)-interacting plant or fungal extract comprising an anthraquinone or anthraquinone derivative, a TOMM6-interacting anthraquinone or anthraquinone derivative, and TOMM6-interacting compounds for use in the treatment or prophylaxis of a nervous system disease, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection. Furthermore, the present invention relates to a corresponding method of therapeutic or prophylactic treatment of a nervous system disease or disorder, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection, as well as to a method for the identification of a TOMM6-interacting compound or composition. Also, the present invention provides a non-human transgenic animal expressing a transgenic, preferably human TOMM6 or a TOMM6 homolog.