3,5-dinitro-4-(propylamino)-1-benzenesulfonamide | 62409-47-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-dinitro-4-(propylamino)-1-benzenesulfonamide
• 英文别名: 3,5-Dinitro-4-(propylamino)benzenesulfonamide
• CAS: 62409-47-6
• 化学式: C₉H₁₂N₄O₆S
• 分子量: 304.283
• InChiKey: IOJAESFEVURKSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  172
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-氯-3,5-二硝基苯磺酸 在 五氯化磷 、 氨 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 3,5-dinitro-4-(propylamino)-1-benzenesulfonamide
  参考文献：
  名称：

  Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin

  摘要：

  Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound 20 displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00465-1

文献信息

• Benbow, John W.; Bernberg, Erin L.; Korda, Anna, Antimicrobial Agents and Chemotherapy, 1998, vol. 42, # 2, p. 339 - 343
  作者：Benbow, John W.、Bernberg, Erin L.、Korda, Anna、Mead, Jan R.

  DOI：——

  日期：——
• Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin
  作者：Gautam Bhattacharya、Manar M Salem、Karl A Werbovetz

  DOI：10.1016/s0960-894x(02)00465-1

  日期：2002.9

  Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound 20 displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin. (C) 2002 Elsevier Science Ltd. All rights reserved.