5-phenyl-pyrimidine-2,4,6-triyltriamine | 103274-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-phenyl-pyrimidine-2,4,6-triyltriamine
• 英文别名: 5-Phenyl-pyrimidin-2,4,6-triyltriamin；5-Phenylpyrimidine-2,4,6-triamine
• CAS: 103274-39-1
• 化学式: C₁₀H₁₁N₅
• 分子量: 201.231
• InChiKey: UPELUPPNZNMFBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-phenyl-pyrimidine-2,4,6-triyltriamine 在 硫酸 、 potassium nitrate 作用下， 生成 5-(4-nitro-phenyl)-pyrimidine-2,4,6-triyltriamine
  参考文献：
  名称：

  DE956306

  摘要：

  公开号：
• 作为产物：
  描述：

  6-chloro-5-phenyl-pyrimidine-2,4-diyldiamine 在 乙醇 、 氨 作用下， 生成 5-phenyl-pyrimidine-2,4,6-triyltriamine
  参考文献：
  名称：

  DE956306

  摘要：

  公开号：

文献信息

• USE OF GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS
  申请人：Synaptic Pharmaceutical Corporation

  公开号：EP1363638A2

  公开（公告）日：2003-11-26
• [EN] USE OF GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS<br/>[FR] UTILISATION D'ANTAGONISTES DU RECEPTEUR GAL3 DANS LE TRAITEMENT DE LA DEPRESSION ET/OU DE L'ANXIETE ET COMPOSES UTILES DANS DE TELLES METHODES
  申请人：SYNAPTIC PHARMA CORP

  公开号：WO2002060392A2

  公开（公告）日：2002-08-08

  This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and apharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.
• DE956306
  申请人：——

  公开号：——

  公开（公告）日：——