乙基3-(3,5-二氟苯基)丙酸酯 | 163978-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 乙基3-(3,5-二氟苯基)丙酸酯
• 中文别名: 3-(3,5-二氟-苯基)-丙酸乙基酯
• 英文名称: ethyl 3-(3,5-difluorophenyl)propionate
• 英文别名: 3-(3,5-difluorophenyl) propionic acid ethyl ester；Ethyl 3-(3,5-difluorophenyl)propanoate
• CAS: 163978-51-6
• 化学式: C₁₁H₁₂F₂O₂
• 分子量: 214.212
• InChiKey: RJPFVVQBZAJMKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙基3-(3,5-二氟苯基)丙酸酯 在 二异丁基氢化铝 、 magnesium sulfate 作用下， 以 乙醚 、 甲苯 为溶剂， 以98.8%的产率得到3-(3,5-二氟苯基)丙醛
  参考文献：
  名称：

  Dioxane derivatives, liquid-crystal compositions containing the same, and liquid-crystal display devices made by using the same

  摘要：

  本发明提供了具有高电压保持比和显着高Δε值、电学稳定性和化学稳定性的液晶化合物，该化合物与已知的液晶化合物具有良好的相容性，包含该化合物的液晶组合物，以及通过使用该化合物构成的液晶显示装置。本发明的液晶化合物是特定的二氧杂环己烷衍生物，表示为通式（1）。此外，本发明涉及具有以下特征的液晶组合物，即该组合物至少包括上述衍生物之一，并且通过使用该组合物构成的液晶显示装置。

  公开号：

  US06235355B1
• 作为产物：
  描述：

  ethyl 3-(3,5-difluorophenyl)acrylate 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 生成 乙基3-(3,5-二氟苯基)丙酸酯
  参考文献：
  名称：

  Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils.

  摘要：

  A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine and 5-fluorouracil and to ameliorate zidovudine-induced anemia in animal models. We prepared a series of 5-aryl-substituted analogues of 5-benzylacyclouridine (BAU), a good inhibitor of UrdPase (IC50 of 0.46 mu M), to develop a compound with enhanced potency and improved pharmacokinetics. The first phase of structure-activity relationship studies on a series of 32 aryl-substituted 5-benzyluracils found several 5-(3-alkoxybenzyl) analogues of 5-benzyluracil with enhanced potency. The acyclovir side chain, the (2-hydroxyethoxy)methyl group, was substituted on the more potent aryl-substituted 5-benzyluracils. The two most potent compounds, 10y (3-propoxy) and 10dd (3-sec-butoxy), were inhibitors of UrdPase with IC(50)s of 0.047 and 0.027 mu M, respectively. Six compounds were tested in vivo for effects on steady-state concentrations of circulating uridine in rats. Plasma uridine levels were elevated 3-9-fold by compound levels that ranged from 8 to 50 mu M.

  DOI：

  10.1021/jm00019a015

文献信息

• DIOXANE DERIVATIVES, LIQUID-CRYSTAL COMPOSITIONS CONTAINING THE SAME, AND LIQUID-CRYSTAL DISPLAY DEVICES MADE BY USING THE SAME
  申请人：CHISSO CORPORATION

  公开号：EP0881221A1

  公开（公告）日：1998-12-02

  The present invention provides liquid crystalline compounds having a high voltage holding ratio and a remarkably high Δ ε value, electric and chemical stability, and having good compatibility with known liquid crystalline compounds, liquid crystal compositions containing the compound, and liquid crystal display devices constituted by using the compounds. The liquid crystalline compounds of the present invention are particular dioxane derivatives represented by general formula (1). Further, the present invention relates to liquid crystal compositions characterized in that the compositions comprise at least one of the derivatives, and liquid crystal display devices constituted by using the compositions.

  本发明提供的液晶化合物具有较高的电压保持率和显着较高的Δ ε 值、电气和化学稳定性，并且与已知液晶化合物、含有该化合物的液晶组合物和使用该化合物构成的液晶显示设备具有良好的兼容性。 本发明的液晶化合物是由通式（1）表示的特定二恶烷衍生物。此外，本发明还涉及液晶组合物，其特征在于该组合物包含至少一种衍生物，以及使用该组合物构成的液晶显示装置。
• Epoxidation with dioxiranes derived from 2-fluoro-2-substituted-1-tetralones and -1-indanones
  作者：David S. Brown、Brian A. Marples、Paul Smith、Lesley Walton

  DOI：10.1016/0040-4020(95)00075-j

  日期：1995.3

  Homochiral 2-fluoro-2-substituted-1-tetralones (10a, 10b, 13) and ethyl 2-fluoro-1-indanone-2-carboxylate (16) have been isolated. The dioxirane derivatives of these ketones have been prepared in situ, and have been shown to epoxidise alkenes but not enantioselectively. The dioxirane derivative of methyl 2,5,7-trifluoro-1-indanone-2-carboxylate (18) has been shown to be comparatively efficient in epoxidation.
• US6235355B1
  申请人：——

  公开号：US6235355B1

  公开（公告）日：2001-05-22