7-methoxy-4-phenyl-6-phenylmethoxy-2H-chromene | 934815-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 7-methoxy-4-phenyl-6-phenylmethoxy-2H-chromene
• CAS: 934815-40-4
• 化学式: C₂₃H₂₀O₃
• 分子量: 344.41
• InChiKey: REIHDSMSLGBAJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  ——	1-Methoxy-4-(1-phenylethenyl)-2-phenylmethoxy-5-prop-2-enoxybenzene	934815-38-0	C25H24O3	372.464

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  黄檀色烯	dalbergichromene	32066-31-2	C16H14O3	254.285

反应信息

• 作为反应物：
  描述：

  7-methoxy-4-phenyl-6-phenylmethoxy-2H-chromene 在 palladium dihydroxide 2,3-二氯-5,6-二氰基-1,4-苯醌 、 环己烯 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 1.0h， 生成 黄檀素
  参考文献：
  名称：

  New syntheses of dalbergichromene and dalbergin from vanillin via neoflavene intermediate

  摘要：

  In this Letter, naturally occurring dalbergichromene and dalbergin were synthesized from a common neoflavene intermediate, which was derived from vanillin. The giving neoflavene intermediate was debenzylated with AlCl3 to yield dalbergichromene in 39% total yield, and it was oxidized by DDQ, and subsequently debenzylated by Pd(OH)(2)/C and cyclohexene in refluxing ethanol to give dalbergin in 31% total yield. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.01.117
• 作为产物：
  描述：

  4-苄氧基-3-甲氧基苯甲醛 在 Grubbs' catalyst (II) potassium tert-butylate 、 potassium carbonate 、 间氯过氧苯甲酸 、 zinc(II) oxide 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 31.0h， 生成 7-methoxy-4-phenyl-6-phenylmethoxy-2H-chromene
  参考文献：
  名称：

  New syntheses of dalbergichromene and dalbergin from vanillin via neoflavene intermediate

  摘要：

  In this Letter, naturally occurring dalbergichromene and dalbergin were synthesized from a common neoflavene intermediate, which was derived from vanillin. The giving neoflavene intermediate was debenzylated with AlCl3 to yield dalbergichromene in 39% total yield, and it was oxidized by DDQ, and subsequently debenzylated by Pd(OH)(2)/C and cyclohexene in refluxing ethanol to give dalbergin in 31% total yield. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.01.117