2-nitrobenzyl-11-mercaptoundecanoate | 936750-89-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitrobenzyl-11-mercaptoundecanoate
• 英文别名: 2-Nitrobenzyl 11-mercaptoundecanoate；(2-nitrophenyl)methyl 11-sulfanylundecanoate
• CAS: 936750-89-9
• 化学式: C₁₈H₂₇NO₄S
• 分子量: 353.483
• InChiKey: NPGWASYTOOUHGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  73.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  11-巯基十一烷酸 、 邻硝基苯甲醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-nitrobenzyl-11-mercaptoundecanoate
  参考文献：
  名称：

  A Multilayered Approach to Complex Surface Patterning

  摘要：

  A method for developing complex nanopatterns on surfaces has been developed by combining self-assembly, photolabile protecting groups, and in multilayered films. An o-nitrobenzyl protecting group has been incorporated into molecular level films utilizing thiol-gold interactions. When the o-nitrobenzyl group is cleaved by ultraviolet light, a carboxylic acid terminated layer remains on the surface and is available for activation and further functionalization through amide bond formation. Using this method, multilayered films have been constructed and characterized by contact angle goniometry, cyclic voltammetry, grazing incidence infrared spectroscopy, and X-ray photoelectron spectroscopy measurements. Complex surface patterns can be achieved by creating, a surface using a photomask and then further functionalizing the irradiated area through covalent coupling. Fluorophores were attached to the deprotected regions, providing visual evidence of surface patterning using fluorescence microscopy. This approach is universal to bind moietics containing free amine groups at defined regions across a surface, allowing, for the development of films with complex chemical and physicochemical properties.

  DOI：

  10.1021/la902966b

文献信息

• IMAGEWISE PATTERNING OF FILMS AND DEVICES COMPRISING THE SAME
  申请人：McGimpsey W. Grant

  公开号：US20090220381A1

  公开（公告）日：2009-09-03

  The present invention is directed, at least in part, to methods for imagewise patterning of a surface. Such patterned surfaces can be used, e.g., in microfluidic devices. Accordingly, the present invention is also directed, at least in part, to nanopatterned devices which include a microchannel structure and methods for forming such devices.

  本发明至少部分涉及表面的图像化图案方法。这种图案化的表面可以用于微流体设备等。因此，本发明至少部分涉及纳米图案化设备，其中包括微通道结构和形成这种设备的方法。
• Imagewise patterning of films and devices comprising the same
  申请人：Worcester Polytechnic Institute

  公开号：US08076125B2

  公开（公告）日：2011-12-13

  The present invention is directed, at least in part, to methods for imagewise patterning of a surface. Such patterned surfaces can be used, e.g., in microfluidic devices. Accordingly, the present invention is also directed, at least in part, to nanopatterned devices which include a microchannel structure and methods for forming such devices.

  本发明至少部分地涉及表面的图像化图案方法。这样的图案化表面可以用于微流体装置等。因此，本发明至少部分地涉及纳米图案化装置，其中包括微通道结构和形成这样的装置的方法。
• A Multilayered Approach to Complex Surface Patterning
  作者：Peter F. Driscoll、Eftim Milkani、Christopher R. Lambert、W. Grant McGimpsey

  DOI：10.1021/la902966b

  日期：2010.3.2

  A method for developing complex nanopatterns on surfaces has been developed by combining self-assembly, photolabile protecting groups, and in multilayered films. An o-nitrobenzyl protecting group has been incorporated into molecular level films utilizing thiol-gold interactions. When the o-nitrobenzyl group is cleaved by ultraviolet light, a carboxylic acid terminated layer remains on the surface and is available for activation and further functionalization through amide bond formation. Using this method, multilayered films have been constructed and characterized by contact angle goniometry, cyclic voltammetry, grazing incidence infrared spectroscopy, and X-ray photoelectron spectroscopy measurements. Complex surface patterns can be achieved by creating, a surface using a photomask and then further functionalizing the irradiated area through covalent coupling. Fluorophores were attached to the deprotected regions, providing visual evidence of surface patterning using fluorescence microscopy. This approach is universal to bind moietics containing free amine groups at defined regions across a surface, allowing, for the development of films with complex chemical and physicochemical properties.