2,4-二羟基-N-(2-羟乙基)苯甲酰胺 | 24207-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二羟基-N-(2-羟乙基)苯甲酰胺
• 中文别名: 2,4-二羟基苯甲酸乙醇酰胺
• 英文名称: 2,4-dihydroxy-N-(2-hydroxy-ethyl)benzamide
• 英文别名: 2,4-Dihydroxy-N-(2-hydroxyethyl)benzamide
• CAS: 24207-41-8
• 化学式: C₉H₁₁NO₄
• mdl: MFCD00002835
• 分子量: 197.191
• InChiKey: HHSJOVPBCHTADG-UHFFFAOYSA-N

物化性质

• 熔点：
  163-165 °C(lit.)
• 沸点：
  547.1±29.0 °C(Predicted)
• 密度：
  1.401±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  在常温常压下稳定，应避免接触强氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2924299090
• 安全说明：
  S26,S37/39

制备方法与用途

用途：用于制备重氮偶合剂、硫化剂和感光剂等。

反应信息

• 作为反应物：
  描述：

  2,4-二羟基-N-(2-羟乙基)苯甲酰胺 生成 2,3-dihydro-7-hydroxy-3-(2'-hydroxyethyl)-4H-1,3-benzoxazin-4-one
  参考文献：
  名称：

  Benzoxazinone and benzothiazinone derivatives having cardiovascular

  摘要：

  化合物的式子为I ##STR1## 其中R代表氢，C.sub.1-C.sub.6烷基，C.sub.5-C.sub.7环烷基，亚甲二氧基或苯基，其可以被一个或两个基团独立地选择从羟基，卤素，硝基，C.sub.1-C.sub.6烷基或C.sub.1-C.sub.6烷氧基取代；R.sub.1和R.sub.2独立地代表氢，COOR.sub.3，--CONR.sub.4 R.sub.5，##STR2##--OCONR.sub.4 R.sub.5，--OCOR.sub.3，--NR.sub.4 R.sub.5，--OCOOR.sub.6，--NR.sub.3 COR.sub.7，--NR.sub.CONR.sub.4 R.sub.5，--N.dbd.CH--NR.sub.4 R.sub.5，NO.sub.2，CN，OH，SR.sub.3，其中R.sub.3为氢或C.sub.1-C.sub.6烷基，R.sub.4和R.sub.5独立地为氢或C.sub.1-C.sub.6烷基，R.sub.6为C.sub.1-C.sub.6烷基，而R.sub.7为氢，C.sub.1-C.sub.6烷基或C.sub.1-C.sub.6烷氧基，其中R.sub.1和R.sub.2不能同时为氢；X为氧或硫；Y表示C.sub.2-C.sub.6烷基链或C.sub.5-C.sub.7环烷基团；提供其药学上可接受的盐，并可用于制备药物组合物，用于治疗心血管疾病。

  公开号：

  US05480882A1
• 作为产物：
  描述：

  2,4-二羟基苯甲酸甲酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2,4-二羟基-N-(2-羟乙基)苯甲酰胺
  参考文献：
  名称：

  DE896453

  摘要：

  公开号：

文献信息

• [EN] ISOINDOLIN-1-ONE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOINDOLIN-1-ONE
  申请人：CANCER REC TECH LTD

  公开号：WO2006024837A1

  公开（公告）日：2006-03-09

  A compound of formula (1) or a prodrug and/or pharmaceutically acceptable salt thereof, wherein X is selected from O, N or S; R1 is selected from hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R2 is selected from hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R3 is selected from hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R4-R7, is used to represent groups R4, R5, R6 and R7 which are independently selected from H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF3, NH2, NO2, COOH, C=0.

  式（1）的化合物或其前药和/或药用可接受的盐，其中X选择自O、N或S；R1选择自氢、卤素、羟基、取代或未取代的烷基、取代或未取代的羟基烷基、取代或未取代的烷基胺、烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基或杂环芳基；R2选择自氢、卤素、羟基、取代或未取代的烷基、取代或未取代的羟基烷基、取代或未取代的烷基胺、烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基或杂环芳基；R3选择自氢、卤素、羟基、取代或未取代的合金取代或未取代的羟基烷基、取代或未取代的烷基胺烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基或杂环芳基；R4-R7，用于表示独立选择自H、OH、烷基、烷氧基、烷基胺、羟基烷基、卤素、CF3、NH2、NO2、COOH、C=0的基团R4、R5、R6和R7。
• [EN] CATALYST SYSTEM FOR POLYMERISATION OF AN OLEFIN<br/>[FR] SYSTÈME CATALYSEUR POUR LA POLYMÉRISATION D'UNE OLÉFINE
  申请人：SAUDI BASIC IND CORP

  公开号：WO2015022298A1

  公开（公告）日：2015-02-19

  The present invention relates to a catalyst system comprising a procatalyst, a co-catalyst and an external electron donor, wherein the external electron donor comprises a compound having the structure according to Formula I: Si (L)n (OR11)4-n (Formula I), wherein, Si is a silicon atom with valency 4+; O is an oxygen atom with valency 2- and O is bonded to Si via the silicon-oxygen bond; n is 1, 2, 3 or 4; R11 is a selected from the group consisting of linear, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; L is a group represented by (Formula II), wherein, L is bonded to the silicon atom via the nitrogen-silicon bond; L has a single substituent on the nitrogen atom, where this single substituent is an imine carbon atom; and X and Y are independently selected from the group consisting of a hydrogen atom; a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements; a linear, branched and cyclic alkyl having at most 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements and an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 7 of the IUPAC Periodic Table of the Elements.

  本发明涉及一种催化剂体系，包括原催化剂、协同催化剂和外部电子供体，其中外部电子供体包括具有以下结构的化合物：Si（L）n（OR11）4-n（式I），其中，Si是具有4价的硅原子；O是具有2价的氧原子，通过硅氧键与Si相连；n为1、2、3或4；R11选自具有最多20个碳原子的线性、支链和环烷基以及具有6至20个碳原子的芳香族取代和未取代的烃基；L是由（式II）表示的一组，其中，L通过氮硅键与硅原子相连；L在氮原子上具有单个取代基，该单个取代基为亚胺碳原子；X和Y分别选自IUPAC元素周期表的13、14、15、16或17族的杂原子、最多含有20个碳原子的线性、支链和环烷基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子，以及具有6至20个碳原子的芳香族取代和未取代的烃基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子。
• Isoindolin-1-One Derivatives
  申请人：Willems Hendrika Maria Gerarda

  公开号：US20080261917A1

  公开（公告）日：2008-10-23

  A compound of formula or a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S; R 1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R 2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R 3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R 4 -R 7 , is used to represent groups R 4 , R 5 , R 6 and R 7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF 3 , NH 2 , NO 2 , COOH, C=0.

  该化合物的化学式为，或其前体药物和/或其药学上可接受的盐，其中X为O、N或S；R1为氢、卤、羟基、取代或未取代的烷基、取代或未取代的羟基烷基、取代或未取代的烷基胺、烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基烷基或杂环芳基烷基；R2为氢、卤、羟基、取代或未取代的烷基、取代或未取代的羟基烷基、取代或未取代的烷基胺、烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基烷基或杂环芳基烷基；R3为氢、卤、羟基、取代或未取代的烷基、取代或未取代的羟基烷基、取代或未取代的烷基胺、烷氧基、取代或未取代的芳基或杂环芳基、取代或未取代的芳基烷基或杂环芳基烷基；R4-R7用于代表R4、R5、R6和R7的基团，其为H、OH、烷基、烷氧基、烷基胺、羟基烷基、卤、CF3、NH2、NO2、COOH、C=0。
• CATALYST SYSTEM FOR POLYMERISATION OF AN OLEFIN
  申请人：ZUIDEVELD Martin Alexander

  公开号：US20160176998A1

  公开（公告）日：2016-06-23

  The present invention relates to a catalyst system comprising a procatalyst, a co-catalyst and an external electron donor, wherein the external electron donor comprises a compound having the structure according to Formula I: Si(L) n (OR 11 ) 4-n (Formula I), wherein, Si is a silicon atom with valency 4+; O is an oxygen atom with valency 2− and O is bonded to Si via the silicon-oxygen bond; n is 1, 2, 3 or 4; R 11 is a selected from the group consisting of linear, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; L is a group represented by (Formula II), wherein, L is bonded to the silicon atom via the nitrogen-silicon bond; L has a single substituent on the nitrogen atom, where this single substituent is an imine carbon atom; and X and Y are independently selected from the group consisting of a hydrogen atom; a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements; a linear, branched and cyclic alkyl having at most 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements and an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 7 of the IUPAC Periodic Table of the Elements.

  本发明涉及一种催化剂体系，包括原催化剂、协同催化剂和外部电子给体，其中，外部电子给体包括具有以下结构的化合物，即式I：Si（L）n（OR11）4-n（式I），其中，Si是价态为4+的硅原子；O是价态为2-的氧原子，通过硅氧键与Si相连；n为1、2、3或4；R11是从线性、支链和环烷烃中选择的，其最多含有20个碳原子，并且是芳香取代和未取代的烃基，其碳原子数为6至20个；L是由式II表示的基团，其中，L通过氮硅键与硅原子连接；L在氮原子上有一个单取代基团，该单取代基团是亚胺碳原子；X和Y独立地选择自元素周期表中第13、14、15、16或17族的杂原子、最多含有20个碳原子的线性、支链和环烷烃，可选含有元素周期表中第13、14、15、16或17族的杂原子和含有6至20个碳原子的芳香取代和未取代的烃基，可选含有元素周期表中第13、14、15、16或17族的杂原子。
• Diazotype compositions and materials
  申请人：Andrews Paper and Chemical Co., Inc.

  公开号：EP0122523A2

  公开（公告）日：1984-10-24

  The use of soluble methylol compounds from primary or secondary amines or ammonia with formaldehyde in diazotypes improves solution compatibility and prevents coupler migration upon storage of diazotype materials. The methylol compounds may be reacted with couplers separately or added to the coating preparations.

  在重氮涂料中使用由伯胺、仲胺或氨与甲醛组成的可溶性甲醇化合物，可提高溶液的相容性，并防止重氮涂料储存时耦合剂迁移。甲醇化合物可以单独与耦合剂反应，也可以添加到涂层制剂中。

表征谱图