2-(2-acetylhydrazino)-4,6-dimethylpyrimidine | 30234-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-acetylhydrazino)-4,6-dimethylpyrimidine
• 英文别名: 4,6-Dimethyl-2-acetylhydrazino-pyrimidin；acetic acid N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazide；Essigsaeure-[N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazid]；N'-(4,6-dimethylpyrimidin-2-yl)acetohydrazide
• CAS: 30234-42-5
• 化学式: C₈H₁₂N₄O
• mdl: MFCD01460177
• 分子量: 180.209
• InChiKey: JEJNMUAFUCSXCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-肼基-4,6-二甲基嘧啶 、 溶剂黄146 反应 2.0h， 以43%的产率得到2-(2-acetylhydrazino)-4,6-dimethylpyrimidine
  参考文献：
  名称：

  5-Aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. Synthesis from substituted 2(4)-hydrazinopyrimidines and fragmentation under positive electrospray ionization

  摘要：

  Reaction of substituted 2(4)-hydrazinopyrimidines with 3-aryl-1-phenyl-2-propen-1-ones in the presence of a base results prevailingly in 5-aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. The fragmentation path of these compounds under positive electrospray ionization consists in simultaneous decomposition of their heterocyclic fragments.

  DOI：

  10.1134/s1070428016080133

文献信息

• Sirakawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 903,905
  作者：Sirakawa

  DOI：——

  日期：——
• Fabbrini, Gazzetta Chimica Italiana, 1957, vol. 87, p. 1293,1300
  作者：Fabbrini

  DOI：——

  日期：——
• 5-Aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. Synthesis from substituted 2(4)-hydrazinopyrimidines and fragmentation under positive electrospray ionization
  作者：A. V. Erkin、O. S. Yuzikhin、V. I. Krutikov

  DOI：10.1134/s1070428016080133

  日期：2016.8

  Reaction of substituted 2(4)-hydrazinopyrimidines with 3-aryl-1-phenyl-2-propen-1-ones in the presence of a base results prevailingly in 5-aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. The fragmentation path of these compounds under positive electrospray ionization consists in simultaneous decomposition of their heterocyclic fragments.