2-[4-(4-fluorophenoxy)phenyl]-6-methyl-4-[2-(N-piperidinyl)ethoxy]-pyridine | 501667-17-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(4-fluorophenoxy)phenyl]-6-methyl-4-[2-(N-piperidinyl)ethoxy]-pyridine
• 英文别名: 2-[4-(4-Fluorophenoxy)phenyl]-6-methyl-4-(2-piperidin-1-ylethoxy)pyridine
• CAS: 501667-17-0
• 化学式: C₂₅H₂₇FN₂O₂
• 分子量: 406.5
• InChiKey: BVRRONNTZTZWBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-Chloro-2-[4-(4-fluorophenoxy)phenyl]-6-methylpyridine 在 NaH 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-[4-(4-fluorophenoxy)phenyl]-6-methyl-4-[2-(N-piperidinyl)ethoxy]-pyridine
  参考文献：
  名称：

  Aryl substituted pyridines and their use

  摘要：

  本发明涉及式I的芳基取代吡啶化合物：1或其药学上可接受的盐、前药或溶剂，其中Ar和R1-R4在规范中设置。本发明还涉及利用式I的化合物治疗全局和局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩侧索硬化症（ALS），以及治疗、预防或改善急性或慢性疼痛，包括糖尿病神经病变，作为抗耳鸣剂，抗惊厥剂，抗躁狂抑郁剂，局部麻醉剂和抗心律失常剂。

  公开号：

  US20030073724A1

文献信息

• HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS
  申请人：Euro-Celtique S.A.

  公开号：EP1432424A1

  公开（公告）日：2004-06-30
• US6770661B2
  申请人：——

  公开号：US6770661B2

  公开（公告）日：2004-08-03
• [EN] HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS<br/>[FR] DERIVES 2-(4-PHENOXY) PYRIDINE A SUBSTITUTION HETEROCYCLIQUE ET COMPOSES APPARENTES EN TANT QUE BLOQUEURS DE CANAL SODIUM POUR LE TRAITEMENT DE LESIONS NEURONALES ET DE TROUBLES NEURODEGENERATIFS
  申请人：EURO CELTIQUE SA

  公开号：WO2003022285A1

  公开（公告）日：2003-03-20

  This invention relates to aryl substituted pyridines of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Ar is selected from the group consisting of Ar1, Ar2, Ar3 and Ar4, wherein Ar1 is R1 is selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C(O)R10, SO2R10, and OC(O)NH2; R2 is Ym-(CH2)n-Z, wherein Y is O, S or NR11, wherein R11 is hydrogen or alkyl, Z is a saturated heterocyclic ring optionally substituted at one or more carbon atoms, m is 0 or 1, and n is 0-6; or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyothrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.
• Aryl substituted pyridines and their use
  申请人：——

  公开号：US20030073724A1

  公开（公告）日：2003-04-17

  This invention relates to aryl substituted pyridines of Formula I: 1 or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.

  本发明涉及式I的芳基取代吡啶化合物：1或其药学上可接受的盐、前药或溶剂，其中Ar和R1-R4在规范中设置。本发明还涉及利用式I的化合物治疗全局和局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩侧索硬化症（ALS），以及治疗、预防或改善急性或慢性疼痛，包括糖尿病神经病变，作为抗耳鸣剂，抗惊厥剂，抗躁狂抑郁剂，局部麻醉剂和抗心律失常剂。