1-[2-(3-nitro-phenyl)-ethyl]-pyrrolidine | 710351-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(3-nitro-phenyl)-ethyl]-pyrrolidine
• 英文别名: 3-[2-(1-pyrrolidyl)ethyl]nitrobenzene；[2-(3-nitrophenyl)ethyl]pyrrolidine；1-[2-(3-nitrophenyl)ethyl]pyrrolidine
• CAS: 710351-81-8
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: WSONLJWIBLBETM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[2-(3-nitro-phenyl)-ethyl]-pyrrolidine 在 钯 作用下， 以 甲醇 为溶剂， 以to yield 3-(2-pyrrolidinylethyl)phenylamine的产率得到3-(pyrrolidin-1-yl)methylmethylphenylamine
  参考文献：
  名称：

  SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE

  摘要：

  提供了新的取代苯唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。这些新的化合物组合物可以单独使用或与至少一种额外的药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。

  公开号：

  US20120288501A1
• 作为产物：
  描述：

  1-(2,2-dibromovinyl)-3-nitrobenzene 在 sodium tetrahydroborate 、 三氟化硼乙醚 、 水 作用下， 以 四氢呋喃 为溶剂， 生成 1-[2-(3-nitro-phenyl)-ethyl]-pyrrolidine
  参考文献：
  名称：

  Synthesis and biological evaluation of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

  摘要：

  A series of new 4 beta-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4 beta position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.016

文献信息

• Substituted benzazoles and methods of their use as inhibitors of Raf kinase
  申请人：——

  公开号：US20040122237A1

  公开（公告）日：2004-06-24

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的替代苯唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。这些新化合物组合物可以单独使用，也可以与至少一种额外药物结合，用于治疗由Raf激酶介导的疾病，如癌症。
• 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE
  申请人：Player R. Mark

  公开号：US20080114007A1

  公开（公告）日：2008-05-15

  The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R 101 and R 200 are described in the specification.

  本发明针对当前对选择性和强效蛋白酪氨酸激酶抑制剂的需求，提供对c-fms激酶的强效抑制剂。本发明涉及以下式I的新化合物： 或其盐、对映体、互变异构体、结晶、多晶型、无定形、溶剂化物、水合物、酯、前药或代谢物形式，其中A、Y、Z、R 101 和R 200 在说明书中有描述。
• Metasubstituted thiazolidinones, their manufacture and use as a drug
  申请人：Schulze Klaus Volker

  公开号：US20070015759A1

  公开（公告）日：2007-01-18

  This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.

  这项发明涉及一般式(I)的噻唑烷酮及其作为极化样激酶（PLK）抑制剂的创造和用途，用于治疗各种疾病。
• Thiazolidinones, their production and use as pharmaceutical agents
  申请人：Schulze Volker

  公开号：US20060223833A1

  公开（公告）日：2006-10-05

  The invention relates to thiazolidinones of general formula (I) their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases.

  本发明涉及通式（I）的噻唑啉酮及其生产和用作极化样激酶（Plk）抑制剂治疗各种疾病。
• METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG
  申请人：SCHULZE Klause

  公开号：US20100048891A1

  公开（公告）日：2010-02-25

  Thiazolidinones of general formula (I) production thereof and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.

  通式为（I）的噻唑烷酮及其制备方法和用途，作为极化样激酶（PLK）抑制剂治疗各种疾病。