5-氨基-2,3-二羟基苯甲酸 | 773041-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氨基-2,3-二羟基苯甲酸
• 英文名称: 5-amino-2,3-dihydroxybenzoic acid
• CAS: 773041-88-6
• 化学式: C₇H₇NO₄
• 分子量: 169.137
• InChiKey: GIGDAMOOQZMWMC-UHFFFAOYSA-N

物化性质

• 沸点：
  477.6±45.0 °C(Predicted)
• 密度：
  1.672±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-氨基-2,3-二羟基苯甲酸 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 苯甲酸,2,3-二羟基-5-硝基-,甲基酯
  参考文献：
  名称：

  [EN] AMINOSULFONYL SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS
  [FR] AMINOSULFONYLE SUBSTITUE 4-(AMINOMETHYLE)-PIPERIDINE BENZAMIDES UTILISE COMME 5HT4-ANTAGONISTES

  摘要：

  本发明涉及具有5HT4-拮抗性质的式（I）的新化合物。该发明还涉及制备这种新化合物的方法，包括这些新化合物的药物组合物以及这些化合物作为药物的用途。

  公开号：

  WO2005000837A1

文献信息

• [EN] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SERVANT D'ANTAGONISTES DE 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005000838A1

  公开（公告）日：2005-01-06

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括将该新化合物作为药物的药物组合物以及该化合物的药用用途。
• Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht 4-antagonists
  申请人：Bosmans Rene Marie Andre Jean-Paul

  公开号：US20060142339A1

  公开（公告）日：2006-06-29

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式（I）的新化合物。本发明还涉及制备这些新化合物的方法，包含这些新化合物的药物组合物以及这些化合物作为药物的用途。
• 4-(Aminomethyl)-piperidine benzamides as 5ht4 - antagonists
  申请人：Bosmans René Marie André Jean-Paul

  公开号：US20060281753A1

  公开（公告）日：2006-12-14

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式（I）新化合物。本发明还涉及制备这种新化合物的方法，包含这种新化合物的药物组合物以及这些化合物作为药物的用途。
• Aminosulfonyl Substituted 4-(Aminomethyl)-Piperidine Benzamides As 5HT 4-Antagonists
  申请人：BOSMANS Jean-Paul René Marie André

  公开号：US20100087483A1

  公开（公告）日：2010-04-08

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4-拮抗性质的式（I）新化合物。本发明还涉及制备这种新化合物的方法，包含这种新化合物的药物组合物以及这种化合物作为药物的用途。
• Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists for the treatment of gatrointestinal conditions
  申请人：Janssen Pharmaceutica NV

  公开号：EP2305254A1

  公开（公告）日：2011-04-06

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有 5HT4 拮抗特性的式 (I) 新型化合物。本发明还涉及制备此类新型化合物的方法、包含上述新型化合物的药物组合物以及上述化合物的药物用途。