2,3-di-2-pyridyl-5-nitroquinoxaline | 7756-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-di-2-pyridyl-5-nitroquinoxaline
• 英文别名: 5-nitro-2,3-(2'-pyridyl)-quinoxaline；5-nitro-2,3-bis(2-pyridyl)quinoxaline；5-Nitro-2,3-bis-(2)-pyridyl-chinoxalin；5-nitro-2,3-di-pyridin-2-yl-quinoxaline；5-Nitro-2,3-bis-(2-pyridyl)quinoxaline；5-nitro-2,3-dipyridin-2-ylquinoxaline
• CAS: 7756-05-0
• 化学式: C₁₈H₁₁N₅O₂
• 分子量: 329.318
• InChiKey: MMIIROYUIWONJJ-UHFFFAOYSA-N

物化性质

• 熔点：
  198-200 °C
• 沸点：
  497.3±40.0 °C(Predicted)
• 密度：
  1.378±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3-di-2-pyridyl-5-nitroquinoxaline 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 5-Amino-2,3-bis-(2)pyridyl-chinoxalin
  参考文献：
  名称：

  Comparison of FT Raman spectra of some 5-nitroquinoxalines and their electropolymers

  摘要：

  FT Raman spectroscopy was used to characterize a set of five newly synthesized 5-nitroquinoxaline derivatives 2,3-disubstituted with 2-pyrrolyl, 2-furyl, 2-thienyl, phenyl and 2-pyridyl groups. Afterwards the 5-nitroquinoxalines were electrochemically reduced to 5-aminoquinoxalines and electropolymerized as films on the Pt electrode coated with porous Au. Comparing the SERS spectra of polymers with the Raman spectra of monomers, a mechanism of polymerization has been suggested. Specific spectral and electrochemical properties of films based on pyrrole substituted 5-aminoquinoxaline were verified by electropolymeriration of 2,3-dipyrrol-2 ' -yl-5-nitroquinoxaline without a reduction step. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-2860(01)00453-7
• 作为产物：
  描述：

  二(2-吡啶基)乙二酮 、 3-硝基邻苯二胺 以80%的产率得到2,3-di-2-pyridyl-5-nitroquinoxaline
  参考文献：
  名称：

  5-Nitro-2,3-bis(2-pyridyl)quinoxaline

  摘要：

  In the crystal structure of the title compound, C18H11N5O2, two crystallographically independent molecules having the same composition and cis-cis conformation (arrangement of the pyridyl rings) are observed. A C-H...N hydrogen bond links the centrosymmetrically related molecules into a discrete pair [C...N = 3.462 (4) Angstrom], and the structure is stabilized further by pi-pi-stacking interactions between aromatic rings from two adjacent dimers.

  DOI：

  10.1107/s0108270103012022

文献信息

• Vasculostatic agents and methods of use thereof
  申请人：Wrasidlo Wolfgang

  公开号：US20070208019A1

  公开（公告）日：2007-09-06

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  本发明提供了用于治疗与血管稳态受损有关的疾病的方法和组合物。本发明的方法和组合物可用于治疗各种疾病，例如中风、心肌梗死、癌症、缺血/再灌注损伤、自身免疫疾病，如类风湿性关节炎、眼部疾病，如视网膜病变或黄斑退化或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合征、水肿、移植排斥、成人/急性呼吸窘迫综合征（ARDS）等等。
• VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF
  申请人：Wrasidlo Wolfgang

  公开号：US20100278811A1

  公开（公告）日：2010-11-04

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  本发明提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。本发明的方法和组合物可用于治疗各种疾病，例如中风、心肌梗塞、癌症、缺血/再灌注损伤、自身免疫疾病，如类风湿性关节炎、眼部疾病，如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合症、水肿、移植排斥、成人/急性呼吸窘迫综合症（ARDS）等。
• Vasculostatic Agents and Methods of Use Thereof
  申请人：Wrasidlo Wolfgang

  公开号：US20100330030A1

  公开（公告）日：2010-12-30

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  提供用于治疗与血管稳定性受损相关的疾病的组合物和方法。发明的方法和组合物可用于治疗多种疾病，包括中风、心肌梗塞、癌症、缺血/再灌注损伤、自身免疫疾病如类风湿性关节炎、眼部疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合征、水肿、移植排斥、成人/急性呼吸窘迫综合征（ARDS）等。
• A novel box-like dinuclear AgI complex [AgL(CH3CN)]2(ClO4)2 exhibiting extended network linkage of unique μ4-ClO4− via C–H⋯O interactions: synthesis, spectra and crystal structure
  作者：He Liu、Miao Du

  DOI：10.1016/s0022-2860(01)00902-4

  日期：2002.4

  A novel box-like dinuclear Ag-I complex [AgL(CH3CN)](2)(ClO4)(2) (L being 2,3-di-2-pyridyl-5-nitroquinoxaline) has been synthesized and structurally characterized by infrared (IR), UV-Vis spectra and X-ray diffraction. The crystal structure indicates that the two intramolecular Ag-I centers are spanned by two ligands thus forming a unique box-like cyclic dimer. Each Ag-I center is four-coordinated by three nitrogen atoms of two ligands and a CH3CN nitrogen donor in distorted tetrahedral coordination geometry. The most striking feature of this complex resides in the formation of an extended supra-molecular network with unique mu(4)-ClO4- bridging mode through intermolecular C-(HO)-O-... interactions. (C) 2002 Elsevier Science B.V. All rights reserved.
• HEINEMANN, ULRICH;BRANDES, WILHELM;DUTZMANN, STEFAN;HANSS. LER, GERD
  作者：HEINEMANN, ULRICH、BRANDES, WILHELM、DUTZMANN, STEFAN、HANSS. LER, GERD

  DOI：——

  日期：——