(6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 446030-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 英文别名: loracarbef；(6R,7S)-7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS: 446030-23-5
• 化学式: C₁₆H₁₆ClN₃O₄
• 分子量: 349.774
• InChiKey: JAPHQRWPEGVNBT-LWALXPGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 、 二苯甲酮腙 在 palladium 10% on activated carbon mercury(II) oxide 作用下， 生成
  参考文献：
  名称：

  Compositions and methods for treating cancer

  摘要：

  这项发明涉及用于治疗或缓解癌症症状的组合物和方法。该发明的组合物和方法将超致死剂量的辐射（称为热点）直接作用于几乎所有癌细胞类型。

  公开号：

  US20060018908A1
• 作为产物：
  描述：

  7-amino-3-chloro-1-azabicyclo[4.2.0]oct-2-en-8-on-2-carboxylic acid 、 三氟乙酸 生成 (6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  HASHIMOTO, YUKIO;TAKASAWA, SEIGO;HIRATA, TADASHI;MATSUKUMA, IKUO;YOSHIIE,+

  摘要：

  DOI：

文献信息

• Monohydrate solvates of loracarbef
  申请人：Kumar Yatendra

  公开号：US20060205938A1

  公开（公告）日：2006-09-14

  This invention relates to monohydrate solvates of loracarbef. The invention also relates to processes for preparing solvates of loracarbef, crystalline monohydrate of loracarbef from said solvates and pharmaceutical compositions that include the crystalline monohydrate of loracarbef.

  本发明涉及洛拉卡贝芬的一水合物溶剂物。本发明还涉及制备洛拉卡贝芬溶剂物、从所述溶剂物中制备结晶一水合物的工艺以及包括该结晶一水合物的制药组合物。
• Antibiotics for treating biohazardous bacterial agents
  申请人：——

  公开号：US20030176327A1

  公开（公告）日：2003-09-18

  The present invention is directed to methods for the control of strains of bio-hazardous bacterial agents. These agents include: Bacillus anthracis, Yersinia Pestis, Francisella tularensis, Clostridium botulinin, Clostridium Perfringens, Brucella abortis, B milletensis, B suis and Burkholderia mallei . These methods employ treating an infected warm-blooded animal with an antibiotics selected from: Cephalothin, Cefazolin, Cephalexin monohydrate, Cephalexin HCl, Cefaclor, Loracarbef, Erythromycin estolate, Dirithromycin, Cinoxacin, Vancomycin HCl, Tobramycin, Cefamandole, Cefuroxime, Daptomycin, and Oritavancin.

  本发明涉及控制生物危害性细菌制剂菌株的方法。这些菌剂包括 炭疽杆菌、鼠疫耶尔森氏菌、土拉弗氏菌、肉毒梭菌、荚膜梭菌、流产布鲁氏菌、小芽孢杆菌、鼠疫杆菌 和 伯克霍尔德氏菌 .这些方法采用选自以下药物的抗生素来治疗受感染的温血动物：头孢菌素、头孢唑啉、一水头孢菌素、盐酸头孢菌素、头孢克洛、氯拉卡贝夫、红霉素酯、地红霉素、西诺沙星、盐酸万古霉素、妥布霉素、头孢孟多、头孢呋辛、达托霉素和奥里他霉素。
• Compositions useful to treat ocular neovascular diseases and macular degeneration
  申请人：Leonard Todd

  公开号：US20060134226A1

  公开（公告）日：2006-06-22

  The present invention provides a composition that includes: (a) xanthophylls; (b) vitamin C; (c) vitamin E; (d) zinc; and (e) copper. The present invention also provides a method of treating macular degeneration in a human, inhibiting angiogenesis in a human, preventing impairment of the vision or for improving impaired vision of a human whose eye has drusen, and/or treating a disease associated with ocular neovascularitis in a human. The methods include administering to a human in need of such treatment an effective amount of the composition of the present invention.
• FORMULATION TO TREAT EAR INFECTION
  申请人：Choe Won-Taek

  公开号：US20080139545A1

  公开（公告）日：2008-06-12

  The present invention provides a pharmaceutical composition that includes: (a) at least one of a non-aminoglycoside antibiotic and an anti-inflammatory agent; and (b) a biofilm-dissolving agent. The present invention also provides for methods of killing or inhibiting the growth of a fungus by contacting the fungus with a composition of the present invention, methods of killing or inhibiting the growth of a virus by contacting the virus with a composition of the present invention, methods of killing or inhibiting the growth of a bacteria by contacting the bacteria with a composition of the present invention, methods of treating a disorder in a mammal by administering the composition of the present invention to the mammal, methods for preserving contact lens by contacting the contact lens with a composition of the present invention, methods for cleansing surgical or dental instrument by contacting the fungus with a composition of the present invention, and kits that include (a) a container that includes the pharmaceutical composition of the present invention, and (b) a drug delivery device.
• CARBACEPHEM BETA-LACTAM ANTIBIOTICS
  申请人：Wagman Allan Scott

  公开号：US20110224186A1

  公开（公告）日：2011-09-15

  Carbacephem β-lactam antibiotics having the following chemical structure (I) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar 2 , X, R 1 and R 2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.