4-O-benzyl 1-O-butyl (2S,3R)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-3-(2-methylpropyl)butanedioate | 206555-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-O-benzyl 1-O-butyl (2S,3R)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-3-(2-methylpropyl)butanedioate
• CAS: 206555-11-5
• 化学式: C₂₅H₃₈O₇
• 分子量: 450.573
• InChiKey: QLOYVXDXZKDWGH-IRLDBZIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-O-benzyl 1-O-butyl (2S,3R)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-3-(2-methylpropyl)butanedioate 在 palladium on activated charcoal 盐酸 、 lithium hydroxide 、 氢气 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 1,4-二氧六环 为溶剂， 生成 (9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-diaza-cyclotridecane-9,13-dicarboxylic acid 13-(benzyloxy-amide) 9-methylamide
  参考文献：
  名称：

  基质金属蛋白酶和TNF-α产生的环状抑制剂的设计与合成。

  摘要：

  DOI：

  10.1021/jm970849z
• 作为产物：
  描述：

  (S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one 在 lithium hydroxide 、 双氧水 、 sodium hydride 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium diisopropyl amide 作用下， 生成 4-O-benzyl 1-O-butyl (2S,3R)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-3-(2-methylpropyl)butanedioate
  参考文献：
  名称：

  基质金属蛋白酶和TNF-α产生的环状抑制剂的设计与合成。

  摘要：

  DOI：

  10.1021/jm970849z

文献信息

• Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo
  作者：Chu-Biao Xue、Matthew E. Voss、David J. Nelson、James J.-W. Duan、Robert J. Cherney、Irina C. Jacobson、Xiaohua He、John Roderick、Lihua Chen、Ronald L. Corbett、Li Wang、Dayton T. Meyer、Kenneth Kennedy、William F. DeGrado、Karl D. Hardman、Christopher A. Teleha、Bruce D. Jaffee、Rui-Qin Liu、Robert A. Copeland、Maryanne B. Covington、David D. Christ、James M. Trzaskos、Robert C. Newton、Ronald L. Magolda、Ruth R. Wexler、Carl P. Decicco

  DOI：10.1021/jm010127e

  日期：2001.8.1

  To search for TNF-alpha (tumor necrosis factor alpha) converting enzyme (TACE) inhibitors, we designed a new class of macrocyclic hydroxamic acids by linking the PI and P2 ' residues of acyclic anti-succinate-based hydroxamic acids. A variety of residues including amide, carbamate, alkyl, sulfonamido, Boc-amino, and amino were found to be suitable P1-P2 ' linkers. With an N-methylamide at P3 ', the 13-16-membered macrocycles prepared exhibited low micromolar activities in the inhibition of TNF-alpha release from LPS-stimulated human whole blood. Further elaboration in the P3 ' -P4 ' area using the cyclophane and cyclic carbamate templates led to the identification of a number of potent analogues with IC50 values of less than or equal to 0.2 muM in whole blood assay (WBA). Although the P3 ' area can accommodate a broad array of structurally diversified functional groups including polar residues, hydrophobic residues, and amino and carboxylic acid moieties, in both the cyclophane series and the cyclic carbamate series, a glycine residue at P3 ' was identified as a critical structural component to achieve both good in vitro potency and good oral activity. With a glycine residue at P3 ', an N-methylamide at P4 ' provided the best cyclophane analogue, SL422 (WBA IC50 = 0.22 muM, LPS-mouse ED50 = 15 mg/kg, po), whereas a morpholinylamide at P4 ' afforded the most potent and most orally active cyclic carbamate analogue, SP057 (WBA IC50 = 0.067 muM, LPS-mouse ED50 = 2.3 mg/kg, po). Further profiling for SL422 and SP057 showed that these macrocyclic compounds are potent TACE inhibitors, with K-i values of 12 and 4.2 nM in the porcine TACE assay, and are broad-spectrum MMP inhibitors. Pharmacokinetic studies in beagle dogs revealed that SL422 and SP057 are orally bioavailable, with oral bioavailabilities of 11% and 23%, respectively.
• Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production
  作者：Chu-Biao Xue、Xiaohua He、John Roderick、William F. DeGrado、Robert J. Cherney、Karl D. Hardman、David J. Nelson、Robert A. Copeland、Bruce D. Jaffee、Carl P. Decicco

  DOI：10.1021/jm970849z

  日期：1998.5.1