3-pivaloyloxazolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-pivaloyloxazolidin-2-one
• 英文别名: 3-(2,2-Dimethyl-propionyl)-4-phenyl-oxazolidin-2-one；3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: RCYGSFKQQKHMBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-pivaloyloxazolidin-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 以92%的产率得到N-(1-phenylvinyl)pivalamide
  参考文献：
  名称：

  An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base

  摘要：

  Efficient synthesis of styrenyl enamides can be achieved from the corresponding 4-aryl-2-oxazolidinones, 2-thioxooxazolidines, and 2-thioxothiazolidines in the presence of the strong base lithium diisopropylamine. The reaction proceeded efficiently to achieve the enamides in good to excellent yields (up to 92%). This reaction provides an easy, rapid, and good-yielding method for the synthesis of styrenyl enamides. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.026

文献信息

• US9656963B2
  申请人：——

  公开号：US9656963B2

  公开（公告）日：2017-05-23
• An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base
  作者：Kaihe Zou、Jinxing Ye、Xin-Yan Wu

  DOI：10.1016/j.tetlet.2015.08.026

  日期：2015.10

  Efficient synthesis of styrenyl enamides can be achieved from the corresponding 4-aryl-2-oxazolidinones, 2-thioxooxazolidines, and 2-thioxothiazolidines in the presence of the strong base lithium diisopropylamine. The reaction proceeded efficiently to achieve the enamides in good to excellent yields (up to 92%). This reaction provides an easy, rapid, and good-yielding method for the synthesis of styrenyl enamides. (C) 2015 Elsevier Ltd. All rights reserved.