dicyclohexyl-sulfamoyl chloride | 99700-74-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dicyclohexyl-sulfamoyl chloride
• 英文别名: Dicyclohexylamino-N-sulfochlorid；N-chlorosulfonyldicyclohexylamine；Sulfamoyl chloride, dicyclohexyl-；N,N-dicyclohexylsulfamoyl chloride
• CAS: 99700-74-0
• 化学式: C₁₂H₂₂ClNO₂S
• 分子量: 279.831
• InChiKey: VWNQGADNXRISFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,2S)-1,2-二苯基乙二胺 、 dicyclohexyl-sulfamoyl chloride 以 二氯甲烷 为溶剂， 以35%的产率得到(1S,2S)-N-(N,N-dicyclohexylsulfamoyl)-1,2-diphenylethylenediamine
  参考文献：
  名称：

  New chiral N-(N,N-dialkylamino)sulfamoyl-1,2-diamine ligands for highly enantioselective transfer hydrogenation of ketones

  摘要：

  Chiral Ru(II) and Rh(III) complexes of N-(N,N-dialkylamino)sulfamoyl-1,2-diamine catalyze the transfer hydrogenation of various classes of aromatic ketones with high activity and excellent enantioselectivity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00659-6
• 作为产物：
  描述：

  dicyclohexyl-chloroamine 在 四氯化碳 、 二氧化硫 、 氯 作用下， 生成 dicyclohexyl-sulfamoyl chloride
  参考文献：
  名称：

  Wegler; Bodenbrenner, Justus Liebigs Annalen der Chemie, 1959, vol. 624, p. 25,29

  摘要：

  DOI：

文献信息

• Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation
  申请人：——

  公开号：US20020160978A1

  公开（公告）日：2002-10-31

  This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthase inhibitor.

  本发明提供了一种用于治疗需要治疗骨关节炎的受试者的方法，该方法包括向所述受试者施用一定量的亚精胺生物合成抑制剂，其用量足以对亚精胺生物合成产生实质性抑制作用。本发明还提供了一种精胺生物合成抑制剂在治疗需要治疗骨关节炎的受试者中的用途，其用量足以对精胺的生物合成产生实质性的抑制作用。本发明进一步提供了一种用于治疗需要治疗骨关节炎的受试者的治疗组合物的制备方法，本发明进一步提供了一种鉴定亚精胺生物合成抑制剂的方法，其中所述抑制剂为亚精胺合成酶抑制剂。
• INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION
  申请人：Quark Biotech, Inc.

  公开号：EP1357881A2

  公开（公告）日：2003-11-05
• EP1357881A4
  申请人：——

  公开号：EP1357881A4

  公开（公告）日：2009-02-18
• US6696454B2
  申请人：——

  公开号：US6696454B2

  公开（公告）日：2004-02-24
• [EN] INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION<br/>[FR] INHIBITEURS DE LA SPERMIDINE SYNTASE POUR LE TRAITEMENT DE L'ARTHROSE ET POUR LA REHABILITATION DU CARTILAGE
  申请人：QUARK BIOTECH INC

  公开号：WO2002058623A2

  公开（公告）日：2002-08-01

  This invention provides a method for the treatment of a subject in need of treatment for ostheoarthritis comprising administering to said subject an amount of an inhibitor of spermidien biosynthesis sufficient to effect a substantial inhibition of spermidien biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthase inhibitor.