3-methyl-2-(1-methylhydrazinyl)pyridine | 1379047-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methyl-2-(1-methylhydrazinyl)pyridine
• 英文别名: 1-methyl-1-(3-methylpyridin-2-yl)hydrazine
• CAS: 1379047-63-8
• 化学式: C₇H₁₁N₃
• 分子量: 137.184
• InChiKey: DLSSJBVOUGLFKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-3-(3-(3,5-双(三氟甲基)苯基)-1H-1,2,4-三唑-1-基)丙烯酸 、 3-methyl-2-(1-methylhydrazinyl)pyridine 在 1-丙基磷酸酐 、 N,N-二异丙基乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 4.0h， 以40%的产率得到(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-methyl-N'-(3-methylpyridin-2-yl)acrylohydrazide
  参考文献：
  名称：

  [EN] HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
  [FR] MODULATEURS DE TRANSPORT NUCLÉAIRE CONTENANT DE L'HYDRAZIDE ET LEURS UTILISATIONS

  摘要：

  这项发明通常与核运输调节剂有关，例如CRM1抑制剂，更具体地涉及一种由结构式(I)表示的化合物，或其药学上可接受的盐，其中变量的值和备选值如本文所定义和描述。该发明还包括合成和使用结构式I的化合物，或其药学上可接受的盐或组合物，例如在与CRM1活性相关的生理状况的治疗、调节和/或预防中的应用。

  公开号：

  WO2013019548A1

文献信息

• Hydrazide Containing Nuclear Transport Modulators And Uses Thereof
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20150274698A1

  公开（公告）日：2015-10-01

  The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

  本发明通常涉及核运输调节剂，例如CRM1抑制剂，更具体地涉及由结构式I表示的化合物：或其药学上可接受的盐，其中变量的值和可替换值如本文所定义和描述。本发明还包括合成和使用结构式I的化合物，或其药学上可接受的盐或组合物，例如在治疗、调节和/或预防与CRM1活性相关的生理状况中的应用。
• Hydrazide containing nuclear transport modulators and uses thereof
  申请人：Sandanayaka Vincent P.

  公开号：US09079865B2

  公开（公告）日：2015-07-14

  The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

  该发明通常涉及核运输调节剂，例如，CRM1抑制剂，更具体地涉及由结构式（I）表示的化合物或其药学上可接受的盐，其中变量的值和可选值如本文所定义和描述。该发明还包括合成和使用结构式I的化合物，或其药学上可接受的盐或组合物，例如在处理，调节和/或预防与CRM1活性相关的生理状况中的应用。
• HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
  申请人：Karyopharm Therapeutics, Inc.

  公开号：US20140235653A1

  公开（公告）日：2014-08-21

  The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

  本发明通常涉及核运输调节剂，例如CRM1抑制剂，更具体地涉及由结构式I表示的化合物或其药学上可接受的盐，其中变量和备选变量的值如本文所定义和描述的那样。本发明还包括合成和使用结构式I的化合物，或其药学上可接受的盐或组合物，例如在治疗、调节和/或预防与CRM1活性相关的生理状况中使用。
• Hydrazide Containing Nuclear Transport Modulators and Uses Thereof
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20160304472A1

  公开（公告）日：2016-10-20

  The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
• US8999996B2
  申请人：——

  公开号：US8999996B2

  公开（公告）日：2015-04-07