2-(溴甲基)-1,4-亚苯基二乙酸酯 | 6461-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 2-(溴甲基)-1,4-亚苯基二乙酸酯
• 英文名称: 2-Brommethyl-hydrochinon-diacetat
• 英文别名: 2-(Bromomethyl)-1,4-phenylene diacetate；[4-acetyloxy-3-(bromomethyl)phenyl] acetate
• CAS: 6461-38-7
• 化学式: C₁₁H₁₁BrO₄
• 分子量: 287.11
• InChiKey: QSPOOMGBOYTAEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  2-(溴甲基)-1,4-亚苯基二乙酸酯 在 chromium dichloride 、 乙醚 、 三氟化硼 作用下， 生成 Acetic acid 2-methyl-benzofuran-5-yl ester
  参考文献：
  名称：

  还原丙烯酰胺基团的邻苯二甲酰亚胺基团：酯类：非邻苯二甲酸二苄酯的丙酮酸酯和新的制备苯并二氟呋喃酮的取代基，在第2位1 1

  摘要：

  由-O-酰基苄基溴化物经CrCl 2还原而形成的σ键合有机铬（III）配合物经历了酯酰基官能团的1,5-转移，这允许通过选择的实验条件或者选择性地获得非掩蔽的羟基苯甲酮或2-取代的苯并γ-b呋喃的新制备方法。介绍了该方法的范围和局限性。

  DOI：

  10.1016/s0040-4020(01)87790-5
• 作为产物：
  描述：

  2,5-二乙酰氧基甲苯 在 氯仿 、 溴 作用下， 生成 2-(溴甲基)-1,4-亚苯基二乙酸酯
  参考文献：
  名称：

  Lower bound estimation of hardware resources for scheduling in high-level synthesis

  摘要：

  In high-level synthesis of VLSI circuits, good lower bound prediction can efficiently narrow down the large space of possible designs. Previous approaches predict the lower bound by relaxing or even ignoring the precedence constraints of the data flow graph (DFG), and result in inaccuracy of the lower bound. The loop folding and conditional branch were also not considered. In this paper, a new stepwise refinement algorithm is proposed, which takes consideration of precedence constraints of the DFG to estimate the lower bound of hardware resources under time constraints. Processing techniques to handle multi-cycle, chaining, pipelining, as well as loop folding and mutual exclusion among conditional branches are also incorporated in the algorithm. Experimental results show that the algorithm can produce a very tight and close to optimal lower bound in reasonable computation time.

  DOI：

  10.1007/bf02960762

文献信息

• Griseolic acid monoesters, their preparation and use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0319316A2

  公开（公告）日：1989-06-07

  Monoester griseolic acid derivatives of formula (I): (in which: R1 and R2 are the same or different and each represents a hydrogen atom, a hydroxy group or a protected hydroxy group; R3 and R4 each represents a hydrogen atom, or together represent an extra carbon-carbon bond between the two carbon atoms to which they are attached; one of RS and R6 represents a hydrogen atom and the other represents a carboxy-protecting group removable in the biochemical environment of the human eye); and pharmaceutically acceptable salts thereof have been found to have valuable properties in the treatment of ophthalmic disorders. They may be prepared by the selective esterification of the appropriate free acid.

  式(I)的单酯格栅羧酸衍生物： 其中R1和R2相同或不同，各自代表一个氢原子、一个羟基或一个受保护的羟基；R3和R4各自代表一个氢原子，或共同代表它们所连接的两个碳原子之间的一个额外的碳-碳键；RS和R6中的一个代表氢原子，另一个代表可在人眼的生化环境中去除的羧基保护基团）；以及它们的药学上可接受的盐类已被发现在治疗眼科疾病方面具有宝贵的特性。它们可以通过选择性酯化适当的游离酸来制备。
• Preparation of Acetoxybenzyl Bromides
  作者：D. L. Fields、J. B. Miller、D. D. Reynolds

  DOI：10.1021/jo01032a040

  日期：1964.9
• The Preparation of Mercaptomethyl Hydroquinones, Catechols, and Related Compounds
  作者：D. L. Fields、J. B. Miller、D. D. Reynolds

  DOI：10.1021/jo01022a522

  日期：1965.11
• Azonia Polycyclics from Hydroquinone and Catechols
  作者：D. L. Fields、J. B. Miller、D. D. Reynolds

  DOI：10.1021/jo01012a058

  日期：1965.1
• LEDOUSSAL, B.;GORGUES, A.;LE, COQ A., TETRAHEDRON, 43,(1987) N 24, 5841-5852
  作者：LEDOUSSAL, B.、GORGUES, A.、LE, COQ A.

  DOI：——

  日期：——