tributyl-[(1E,3Z,5E)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexa-1,3,5-trienyl]stannane | 936483-06-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硼酸衍生物
• 英文名称: tributyl-[(1E,3Z,5E)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexa-1,3,5-trienyl]stannane
• CAS: 936483-06-6
• 化学式: C₂₄H₄₅BO₂Sn
• 分子量: 495.141
• InChiKey: RISFJUOSMBZDGX-XJJKAVFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.67
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  、 3-boronoacrolein pinacolate 在 K(N(SiMe₃)2) 作用下， 以 四氢呋喃 为溶剂， 以41%的产率得到tributyl-[(1E,3Z,5E)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexa-1,3,5-trienyl]stannane
  参考文献：
  名称：

  Total Synthesis of 2‘-O-Methylmyxalamide D and (6E)-2‘-O-Methylmyxalamide D

  摘要：

  Hetero-bis-metalated 1,3,5-hexatrienes are employed in the linchpin coupling of synthetic fragments for the convergent construction of the central pentaene of the antifungal agent 2'-O-methylmyxalamide D and its (6E) isomer. Sequential Stille and Suzuki-Miyaura couplings interpolate the boron/tin triene into the pentaene chain. The total synthesis of O-methylmyxalamide D and its (6E) isomer was accomplished efficiently.

  DOI：

  10.1021/ja070265e

文献信息

• Total Synthesis of 2‘-<i>O</i>-Methylmyxalamide D and (6<i>E</i>)-2‘-<i>O</i>-Methylmyxalamide D
  作者：Robert S. Coleman、Xiaoling Lu、Isabelle Modolo

  DOI：10.1021/ja070265e

  日期：2007.4.1

  Hetero-bis-metalated 1,3,5-hexatrienes are employed in the linchpin coupling of synthetic fragments for the convergent construction of the central pentaene of the antifungal agent 2'-O-methylmyxalamide D and its (6E) isomer. Sequential Stille and Suzuki-Miyaura couplings interpolate the boron/tin triene into the pentaene chain. The total synthesis of O-methylmyxalamide D and its (6E) isomer was accomplished efficiently.