2-(1-金刚烷基)-1-(2-碘苯基)胍 | 124190-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(1-金刚烷基)-1-(2-碘苯基)胍
• 中文别名: α.-塔洛-九吡喃糖,1,6-脱水-3,7,8,9-四脱氧-4-O-甲基-2-O-(苯基甲基)-
• 英文名称: N-Adamanty-1-yl-N'-(2-iodophenyl)guanidine
• 英文别名: 2-(1-adamantyl)-1-(2-iodophenyl)guanidine
• CAS: 124190-30-3
• 化学式: C₁₇H₂₂IN₃
• 分子量: 395.286
• InChiKey: UPFHEVQMWVMOST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-adamantylcyanamide 、 2-iodoaniline hydrochloride 以 乙腈 为溶剂， 生成 2-(1-金刚烷基)-1-(2-碘苯基)胍
  参考文献：
  名称：

  Radiosynthesis of .sigma. receptor ligands for positron emission tomography: carbon-11 and fluorine-18 labeled guanidines

  摘要：

  A series of analogues of the potent and selective sigma-receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the sigma-receptor as measured by in vitro [H-3]DTG displacement studies using guinea pig brain tissue. Three of these 1-aryl-3-(1-adamantyl)guanidines were radiolabeled - two with carbon-11 and one with fluorine-18. Radiochemical yields and specific activities were sufficient for these radiotracers to be used in positron emission tomography imaging of the haloperidol-sensitive sigma-receptor.

  DOI：

  10.1021/jm00110a017

文献信息

• Methods of treatment of eye trauma and disorders
  申请人：——

  公开号：US20030027801A1

  公开（公告）日：2003-02-06

  Methods are provided for treatment of eye disorders and injury, including methods for treatment of reduced flow of blood or other nutrients to retinal tissue and/or optic nerve, methods for treatment of retinal ischemia and trauma and methods for treatment for optic nerve injury/damage.

  提供了治疗眼部疾病和损伤的方法，包括治疗流向视网膜组织和/或视神经的血液或其他营养物质减少的方法、治疗视网膜缺血和创伤的方法以及治疗视神经损伤/损坏的方法。
• SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE
  申请人：STATE OF OREGON BY AND THROUGH OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON

  公开号：EP0314690B1

  公开（公告）日：1993-12-29
• METHODS FOR TREATING ANXIETY WITH SIGMA RECEPTOR LIGANDS
  申请人：STATE OF OREGON BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY

  公开号：EP0473671A1

  公开（公告）日：1992-03-11
• USE OF SIGMA-RECEPTORS LIGANDS FOR THE MANUFACTURE OF AN ANXIOLYTIC AGENT
  申请人：STATE OF OREGON BY AND THROUGH OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OREGON HEALTH SC. UNIV. AND OREGON STATE UNIV.

  公开号：EP0473671B1

  公开（公告）日：1994-08-24
• EP0473671A4
  申请人：——

  公开号：EP0473671A4

  公开（公告）日：1992-04-01