3-hydroxy-6-bromocoumarin | 36400-66-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-hydroxy-6-bromocoumarin
• 英文别名: 6-bromo-3-hydroxycoumarin；6-Brom-3-hydroxy-cumarin；6-bromo-3-hydroxy-chromen-2-one；6-Bromo-3-hydroxychromen-2-one
• CAS: 36400-66-5
• 化学式: C₉H₅BrO₃
• 分子量: 241.041
• InChiKey: UXODETGMGZTCJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-6-bromocoumarin 在 3 potassium carbonate 作用下， 反应 60.0h， 生成 8-bromo-2-methyl-9-oxo-9H-furo[2,3-c]benzopyran
  参考文献：
  名称：

  Synthesis of 2-Methyl-9-oxo-9H-furo[2,3-c]benzopyrans and 2-Methyl-3H,4H[1]benzopyrano[3,4-b]pyrrol-4-ones

  摘要：

  DOI：

  10.1080/00397919808004294
• 作为产物：
  描述：

  6-bromo-3-aminocoumarin 在 盐酸 作用下， 生成 3-hydroxy-6-bromocoumarin
  参考文献：
  名称：

  Pavé, Grégoire; Chalard, Pierre; Viaud-Massuard, Marie-Claude, Synlett, 2003, # 7, p. 987 - 990

  摘要：

  DOI：

文献信息

• Methods of generating nanoarrays and microarrays
  申请人：NAUTILUS BIOTECHNOLOGY, INC.

  公开号：US11203612B2

  公开（公告）日：2021-12-21

  The methods described herein provide a means of producing an array of spatially separated proteins. The method relies on covalently attaching each protein of the plurality of proteins to a structured nucleic acid particle (SNAP), and attaching the SNAPs to a solid support.

  本文所述方法提供了一种生产空间分离蛋白质阵列的方法。该方法将多个蛋白质中的每个蛋白质共价连接到结构化核酸颗粒（SNAP）上，并将 SNAP 连接到固体支持物上。
• Miky, Jehane A. A.; Saleh, Nadia M.; Shmeiss, Nadia A. M. M., Journal of the Indian Chemical Society, 1997, vol. 74, # 10, p. 814 - 815
  作者：Miky, Jehane A. A.、Saleh, Nadia M.、Shmeiss, Nadia A. M. M.

  DOI：——

  日期：——
• METHODS OF GENERATING NANOARRAYS AND MICROARRAYS
  申请人：Nautilus Biotechnology, Inc.

  公开号：EP3775196A1

  公开（公告）日：2021-02-17
• METHODS AND SYSTEMS FOR COMPUTATIONAL DECODING OF BIOLOGICAL, CHEMICAL, AND PHYSICAL ENTITIES
  申请人：NAUTILUS BIOTECHNOLOGY, INC.

  公开号：US20210390705A1

  公开（公告）日：2021-12-16

  The present disclosure provides systems and methods for detecting components of an array of biological, chemical, or physical entities. In an aspect, the present disclosure provides a method for detecting an array of biological, chemical, or physical entities, comprising: (a) using one or more light sensing devices, acquiring pixel information from sites in an array, wherein the sites comprise biological, chemical, or physical entities that produce light; (b) processing the pixel information to identify a set of regions of interest (ROIs) corresponding to the sites in the array that produce the light; (c) classifying the pixel information for the ROIs into a categorical classification from among a plurality of distinct categorical classifications, thereby producing a plurality of pixel classifications; and (d) identifying one or more components of the array of biological, chemical, or physical entities based at least in part on the plurality of pixel classifications.
• METHODS AND SYSTEMS FOR INTEGRATED ON-CHIP SINGLE-MOLECULE DETECTION
  申请人：Nautilus Biotechnology, Inc.

  公开号：US20220050049A1

  公开（公告）日：2022-02-17

  The present disclosure provides methods and systems for performing single-molecule detection using fabricated integrated on-chip devices. In an aspect, the present disclosure provides a method for on-chip detection of an array of biological, chemical, or physical entities, comprising: (a) providing an array of light sensing devices; (b) immobilizing the array of biological, chemical, or physical entities on a substrate of the array of light sensing devices; (c) exposing the array of biological, chemical, or physical entities to electromagnetic radiation sufficient to excite the array of biological, chemical, or physical entities, thereby producing an emission signal of the array of biological, chemical, or physical entities; (d) using the array of light sensing devices, acquiring pixel information of the emission signal of the array of biological, chemical, or physical entities without scanning the array of light sensing devices across the array of biological, chemical, or physical entities; and (d) detecting the array of biological, chemical, or physical entities based at least in part on the acquired pixel information.