N-{2-[(3-methoxyphenyl)sulfanyl]benzyl}-N-methylamine | 127926-82-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-{2-[(3-methoxyphenyl)sulfanyl]benzyl}-N-methylamine
• 英文别名: 1-[2-(3-methoxyphenyl)sulfanylphenyl]-N-methylmethanamine
• CAS: 127926-82-3
• 化学式: C₁₅H₁₇NOS
• mdl: MFCD00837527
• 分子量: 259.372
• InChiKey: OIWKOIAIXYFZHR-UHFFFAOYSA-N

物化性质

• 沸点：
  372.0±32.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-{2-[(3-methoxyphenyl)sulfanyl]benzyl}-N-methylamine 在 吡啶盐酸盐 作用下， 反应 0.5h， 以81%的产率得到3-[2-(Methylaminomethyl)phenyl]sulfanylphenol
  参考文献：
  名称：

  Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3294 - 3338

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(3-Methoxyphenylthio)benzoyl chloride 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 水 、 苯 为溶剂， 反应 8.0h， 生成 N-{2-[(3-methoxyphenyl)sulfanyl]benzyl}-N-methylamine
  参考文献：
  名称：

  Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3294 - 3338

  摘要：

  DOI：

文献信息

• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.
• INHIBITOR OF HEME DEGRADATION FOR USE TO IMPROVE ANTIBIOTIC TREATMENT OF MYCOBACTERIUM TUBERCULOSIS INFECTION
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20190201414A1

  公开（公告）日：2019-07-04

  The present invention provides a method of preventing or treating a Mycobacterium tuberculosis (Mtb) infection in a mammal the method comprising administering to the mammal a first inhibitor, wherein the first inhibitor is an inhibitor of heme degradation and wherein the first inhibitor is a metal protoporphyrin, and administering to the mammal a second inhibitor, wherein the second inhibitor is an inhibitor of Mtb, wherein administration of the first and second inhibitors to the mammal prevents or treats Mtb infection in the mammal.
• US8450368B2
  申请人：——

  公开号：US8450368B2

  公开（公告）日：2013-05-28
• Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3294 - 3338
  作者：Jilek, Jiri、Sindelar, Karel、Pomykacek, Josef、Kmonicek, Vojtech、Sedivy, Zdenek、et al.

  DOI：——

  日期：——